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Peptide record

TPDB06705

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06705
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AIHDILKYGKPS
Physicochemical Analysis
C62H100N16O17
RNCEQMFTWV
IK
1341.57
9.65
3
1
5
+1
2.47
-0.333
105.83
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
111.06
2
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
1
G
1
H
2
I
1
L
2
K
0
M
0
F
1
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 2 L: 1 K: 2 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C62H100N16O17
1341.57
9.65
+1
2.47
-0.333
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
10 µM

Target

Pseudomonas aeruginosa ATCC 13388

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E-coli ATCC 11219 (MIC >50 uM), P. aeruginosa ATCC 13388 (MIC 10 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 2.2 uM), K-pneumoniae ATCC 10031 (MIC >5
Evidence 2 Activity

Activity

MIC
Antibacterial
2.2 µM

Target

S. enterica serovar Typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP

Other

active against E-coli ATCC 11219 (MIC >50 uM), P. aeruginosa ATCC 13388 (MIC 10 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 2.2 uM), K-pneumoniae ATCC 10031 (MIC >50 uM), S. aureus ATCC 6538 (MIC 10 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
10 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

dbAMP DRAMP

Other

terica serovar Typhimurium ATCC 14028 (MIC 2.2 uM), K-pneumoniae ATCC 10031 (MIC >50 uM), S. aureus ATCC 6538 (MIC 10 uM).
Evidence 4 Activity

Activity

6% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
6% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural insights into and activity analysis of the antimicrobial peptide myxinidin. | Antimicrob Agents Chemother | 2014
Evidence 5 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.24957834] Some peptides at 50 µM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 µM and 200 µM peptide. | Cytotoxicity: [Ref.24957834] The toxicity of the peptide against Vero cells is 0.7%, 0.7%, 3%, 5% and 10% at peptide concentrations of 1, 20, 50, 100 and 200 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Antimicrob Agents Chemother. 2014 Sep 58(9):5280-90.