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Peptide record

TPDB06692

Antibacterial Anticancer Antifungal Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06692
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
CFQWKRAMRKVR
Physicochemical Analysis
C71H117N25O14S2
NDEGHILPSTY
R
1608.99
12.13
5
0
5
+5
1.44
-1.042
32.50
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
5500
341.83
2
Residue Composition
number
1
A
3
R
0
N
0
D
1
C
0
E
1
Q
0
G
0
H
0
I
0
L
2
K
1
M
1
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 2 M: 1 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
12
C71H117N25O14S2
1608.99
12.13
+5
1.44
-1.042
Evidence Records 9 records
Evidence 1 Activity

Activity

<10% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
<10% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Fungicidal Activity of Human Lactoferrin-Derived Peptides Based on the Antimicrobial ?? Region | Int J Antimicrob Agents | 2011
Evidence 2 Activity

Activity

0% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibiotic-Based Conjugates Containing Antimicrobial HLopt2 Peptide: Design, Synthesis, Antimicrobial and Cytotoxic Activities. | ACS Chem Biol | 2019
Evidence 3 Activity

Activity

0% Cytotoxicity
Toxicity
200 µM
Cytotoxic
0% Cytotoxicity | 200 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Antibiotic-Based Conjugates Containing Antimicrobial HLopt2 Peptide: Design, Synthesis, Antimicrobial and Cytotoxic Activities. | ACS Chem Biol | 2019
Evidence 4 Activity

Activity

0% Cytotoxicity
Toxicity
200 µM
Cytotoxic
0% Cytotoxicity | 200 | µM | target cell: Pig kidney epithelial cells PK1

Target

Pig kidney epithelial cells PK1

Source & Reference

NA
DBAASP
Antibiotic-Based Conjugates Containing Antimicrobial HLopt2 Peptide: Design, Synthesis, Antimicrobial and Cytotoxic Activities. | ACS Chem Biol | 2019
Evidence 5 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Human foreskin fibroblasts Hs27

Target

Human foreskin fibroblasts Hs27

Source & Reference

NA
DBAASP
New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets. | Pharmaceutics | 2022
Evidence 6 Activity

Activity

IC90
Toxicity
>100 µM
Cytotoxic
IC90 | >100 | µM | target cell: Human foreskin fibroblasts Hs27

Target

Human foreskin fibroblasts Hs27

Source & Reference

NA
DBAASP
New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets. | Pharmaceutics | 2022
Evidence 7 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets. | Pharmaceutics | 2022
Evidence 8 Activity

Activity

IC90
Toxicity
>100 µM
Cytotoxic
IC90 | >100 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets. | Pharmaceutics | 2022
Evidence 9 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Chem Biol. 2019 Oct 18 14(10):2233-2242.