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Peptide record

TPDB06679

Antibacterial Hemolysis Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06679
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia PD_Hemolysis
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KIKWILKYWKWS
Physicochemical Analysis
C87H127N19O15
ARNDCEQGHMFPTV
K
1679.08
10.64
4
0
7
+4
-3.58
-0.633
97.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
17990
1071.42
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
1
L
4
K
0
M
0
F
0
P
1
S
0
T
3
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 4 M: 0 F: 0 P: 0 S: 1 T: 0 W: 3 Y: 1 V: 0
Chemical Descriptors
12
C87H127N19O15
1679.08
10.64
+4
-3.58
-0.633
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1-4 µM

Target

Escherichia coli ATCC 25922 or resistant CCARM 1229 or CCARM 1238

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram- E. coli ATCC 25922 or resistant CCARM 1229 or CCARM 1238 (MIC 1-4 uM), S. typhimurium KCTC 1926 or resistant CCARM 8009 or CCARM 8013 (MIC 2-16 uM), P. aerugin
Evidence 2 Activity

Activity

MIC
Antibacterial
2-16 µM

Target

S. typhimurium KCTC 1926 or resistant CCARM 8009 or CCARM 8013

Source & Reference

dbAMP DRAMP

Other

tive against Gram- E. coli ATCC 25922 or resistant CCARM 1229 or CCARM 1238 (MIC 1-4 uM), S. typhimurium KCTC 1926 or resistant CCARM 8009 or CCARM 8013 (MIC 2-16 uM), P. aeruginosa ATCC 27853 or resistant 3592 or 5018 (MIC 4-8 uM), Gram+ S. aureus ATCC 25
Evidence 3 Activity

Activity

MIC
Antibacterial
4-8 µM

Target

Pseudomonas aeruginosa ATCC 27853 or resistant 3592 or 5018

Source & Reference

dbAMP DRAMP

Other

IC 1-4 uM), S. typhimurium KCTC 1926 or resistant CCARM 8009 or CCARM 8013 (MIC 2-16 uM), P. aeruginosa ATCC 27853 or resistant 3592 or 5018 (MIC 4-8 uM), Gram+ S. aureus ATCC 25923 or resistant CCARM 3114 or CCARM 3709 (MIC 0.25-16 uM), L. mo
Evidence 4 Activity

Activity

MIC
Antibacterial
0.25-16 µM

Target

Staphylococcus aureus ATCC 25923 or resistant CCARM 3114 or CCARM 3709

Source & Reference

dbAMP DRAMP

Other

013 (MIC 2-16 uM), P. aeruginosa ATCC 27853 or resistant 3592 or 5018 (MIC 4-8 uM), Gram+ S. aureus ATCC 25923 or resistant CCARM 3114 or CCARM 3709 (MIC 0.25-16 uM), L. monocytogenes KCTC 3710 (MIC 4 uM). Myxinidin2 suppresses inflammatory responses thro
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µM

Target

L. monocytogenes KCTC 3710

Source & Reference

dbAMP DRAMP

Other

8 uM), Gram+ S. aureus ATCC 25923 or resistant CCARM 3114 or CCARM 3709 (MIC 0.25-16 uM), L. monocytogenes KCTC 3710 (MIC 4 uM). Myxinidin2 suppresses inflammatory responses through STAT3 and MAPKs to promote wound he
Evidence 6 Activity

Activity

10% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
10% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and membrane-disruption mechanism of charge-enriched AMPs exhibiting cell selectivity, high-salt resistance, and anti-biofilm properties. | Amino Acids | 2016
Evidence 7 Activity

Activity

30% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
30% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and membrane-disruption mechanism of charge-enriched AMPs exhibiting cell selectivity, high-salt resistance, and anti-biofilm properties. | Amino Acids | 2016
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
400 µM
Hemolytic Cytotoxic
50% Hemolysis | 400 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and membrane-disruption mechanism of charge-enriched AMPs exhibiting cell selectivity, high-salt resistance, and anti-biofilm properties. | Amino Acids | 2016
Evidence 9 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.26450121] 10% hemolysis at 50 µM , 28% hemolysis at 100 µM , 30% hemolysis at 200 µM , 50% hemolysis at 400 µM against human red blood cells | Cytotoxicity: [Ref.26450121] The cell survial rates of normal human keratinocytes (NHK) are 100%, 95.8%, 88.3%, 83.4%, 77.4% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50, 100 µM. Melittin, the control, induced 100% toxicity against NHKs at a concentration of

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2016 Feb 48(2):505-22. doi: 10.1007/s00726-015-2104-0.
Evidence 10 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis