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Peptide record

TPDB06676

Antibacterial Hemolysis Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06676
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, HemoPI, and other sources, with an available 3D structural model.
Sequence
RWWRWWRRWWRR
Physicochemical Analysis
C102H134N36O13
ANDCEQGHILKMFPSTYV
RW
2072.42
13.10
6
0
6
+6
-6.24
-2.700
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
33000
1592.34
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
6
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 6 Y: 0 V: 0
Chemical Descriptors
12
C102H134N36O13
2072.42
13.10
+6
-6.24
-2.700
Evidence Records 4 records
Evidence 1 Activity

Activity

7% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
7% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Comparative functional properties of engineered cationic antimicrobial peptides consisting exclusively of tryptophan and either lysine or arginine. | J Med Microbiol | 2016
Evidence 2 Activity

Activity

IC50
Toxicity
128 µM
Cytotoxic
IC50 | 128 | µM | target cell: Murine macrophage cells J774A.1

Target

Murine macrophage cells J774A.1

Source & Reference

NA
DBAASP
Antibacterial Activity of Novel Cationic Peptides against Clinical Isolates of Multi-Drug Resistant Staphylococcus pseudintermedius from Infected Dogs. | PLoS One | 2014
Evidence 3 Activity

Activity

IC50
Toxicity
128 µM
Cytotoxic
IC50 | 128 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Antibacterial Activity of Novel Cationic Peptides against Clinical Isolates of Multi-Drug Resistant Staphylococcus pseudintermedius from Infected Dogs. | PLoS One | 2014
Evidence 4 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis