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Peptide record

TPDB06661

Antibacterial Hemolysis Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06661
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia PD_Hemolysis
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RIRWILRYWRWS
Physicochemical Analysis
C87H127N27O15
ANDCEQGHKMFPTV
R
1791.14
12.40
4
0
7
+4
-4.30
-0.833
97.50
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
17990
1004.39
2
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
1
L
0
K
0
M
0
F
0
P
1
S
0
T
3
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 3 Y: 1 V: 0
Chemical Descriptors
12
C87H127N27O15
1791.14
12.40
+4
-4.30
-0.833
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1-2 µM

Target

Escherichia coli ATCC 25922 or resistant CCARM 1229 or CCARM 1238

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram- E. coli ATCC 25922 or resistant CCARM 1229 or CCARM 1238 (MIC 1-2 uM), S. typhimurium KCTC 1926 or resistant CCARM 8009 or CCARM 8013 (MIC 2-4 uM), P. aerugino
Evidence 2 Activity

Activity

MIC
Antibacterial
2-4 µM

Target

S. typhimurium KCTC 1926 or resistant CCARM 8009 or CCARM 8013

Source & Reference

dbAMP DRAMP

Other

tive against Gram- E. coli ATCC 25922 or resistant CCARM 1229 or CCARM 1238 (MIC 1-2 uM), S. typhimurium KCTC 1926 or resistant CCARM 8009 or CCARM 8013 (MIC 2-4 uM), P. aeruginosa ATCC 27853 or resistant 3592 or 5018 (MIC 4-8 uM), Gram+ S. aureus ATCC 25
Evidence 3 Activity

Activity

MIC
Antibacterial
4-8 µM

Target

Pseudomonas aeruginosa ATCC 27853 or resistant 3592 or 5018

Source & Reference

dbAMP DRAMP

Other

MIC 1-2 uM), S. typhimurium KCTC 1926 or resistant CCARM 8009 or CCARM 8013 (MIC 2-4 uM), P. aeruginosa ATCC 27853 or resistant 3592 or 5018 (MIC 4-8 uM), Gram+ S. aureus ATCC 25923 or resistant CCARM 3114 or CCARM 3709 (MIC 1-8 uM), L. monocy
Evidence 4 Activity

Activity

MIC
Antibacterial
1-8 µM

Target

Staphylococcus aureus ATCC 25923 or resistant CCARM 3114 or CCARM 3709

Source & Reference

dbAMP DRAMP

Other

8013 (MIC 2-4 uM), P. aeruginosa ATCC 27853 or resistant 3592 or 5018 (MIC 4-8 uM), Gram+ S. aureus ATCC 25923 or resistant CCARM 3114 or CCARM 3709 (MIC 1-8 uM), L. monocytogenes KCTC 3710 (MIC 4 uM). Myxinidin2 and myxinidin3 suppress inflammatory r
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µM

Target

L. monocytogenes KCTC 3710

Source & Reference

dbAMP DRAMP

Other

C 4-8 uM), Gram+ S. aureus ATCC 25923 or resistant CCARM 3114 or CCARM 3709 (MIC 1-8 uM), L. monocytogenes KCTC 3710 (MIC 4 uM). Myxinidin2 and myxinidin3 suppress inflammatory responses through STAT3 and MAPKs to pro
Evidence 6 Activity

Activity

% Hemolysis
Hemolysis
27 45 63 59 %
[Ref.26450121] 27% hemolysis at 50 µM , 45% hemolysis at 100 µM , 63% hemolysis at 200 µM , 59% hemolysis at 400 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Amino Acids. 2016 Feb 48(2):505-22. doi: 10.1007/s00726-015-2104-0.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 7 Activity

Activity

12% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
12% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and membrane-disruption mechanism of charge-enriched AMPs exhibiting cell selectivity, high-salt resistance, and anti-biofilm properties. | Amino Acids | 2016
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
50% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and membrane-disruption mechanism of charge-enriched AMPs exhibiting cell selectivity, high-salt resistance, and anti-biofilm properties. | Amino Acids | 2016
Evidence 9 Activity

Activity

60% Hemolysis
Toxicity
200-400 µM
Hemolytic Cytotoxic
60% Hemolysis | 200-400 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and membrane-disruption mechanism of charge-enriched AMPs exhibiting cell selectivity, high-salt resistance, and anti-biofilm properties. | Amino Acids | 2016
Evidence 10 Activity

Activity

% Hemolysis
Toxicity
27 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.26450121] 27% hemolysis at 50 µM , 45% hemolysis at 100 µM , 63% hemolysis at 200 µM , 59% hemolysis at 400 µM against human red blood cells | Cytotoxicity: [Ref.26450121] The cell survial rates of normal human keratinocytes (NHK) are 100%, 95.8%, 88.3%, 83.4%, 77.4% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50, 100 µM. Melittin, the control, induced 100% toxicity against NHKs at a concentration of

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2016 Feb 48(2):505-22. doi: 10.1007/s00726-015-2104-0.
Evidence 11 Hemolysis

Activity

27 45 63 59 %
% Hemolysis
[Ref.26450121] 27% hemolysis at 50 µM , 45% hemolysis at 100 µM , 63% hemolysis at 200 µM , 59% hemolysis at 400 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

PD_Hemolysis
Amino Acids. 2016 Feb 48(2):505-22. doi: 10.1007/s00726-015-2104-0.
DRAMP4
PD_Hemolysis