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Peptide record

TPDB06609

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06609
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GIRRILKYGKRS
Physicochemical Analysis
C64H115N23O15
ANDCEQHMFPTWV
R
1446.76
12.14
5
0
4
+5
2.44
-0.950
97.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
102.99
2
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
1
L
2
K
0
M
0
F
0
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 1 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C64H115N23O15
1446.76
12.14
+5
2.44
-0.950
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

Escherichia coli ATCC 11219

Source & Reference

NA

Other

active against E. coli ATCC 11219 (MIC 4 uM), P. aeruginosa ATCC 13388 (MIC 10 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 10
Evidence 2 Activity

Activity

MIC
Antibacterial
10 µM

Target

Pseudomonas aeruginosa ATCC 13388

Source & Reference

NA

Other

active against E. coli ATCC 11219 (MIC 4 uM), P. aeruginosa ATCC 13388 (MIC 10 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 10 uM), K. pneumoniae ATCC 10031 (MIC 10
Evidence 3 Activity

Activity

MIC
Antibacterial
10 µM

Target

S. enterica serovar Typhimurium ATCC 14028

Source & Reference

NA

Other

active against E. coli ATCC 11219 (MIC 4 uM), P. aeruginosa ATCC 13388 (MIC 10 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 10 uM), K. pneumoniae ATCC 10031 (MIC 10 uM), S. aureus ATCC 6538 (MIC 5 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
10 µM

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

NA

Other

eruginosa ATCC 13388 (MIC 10 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 10 uM), K. pneumoniae ATCC 10031 (MIC 10 uM), S. aureus ATCC 6538 (MIC 5 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
5 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

NA

Other

nterica serovar Typhimurium ATCC 14028 (MIC 10 uM), K. pneumoniae ATCC 10031 (MIC 10 uM), S. aureus ATCC 6538 (MIC 5 uM).
Evidence 6 Activity

Activity

1% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
1% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013
Evidence 7 Activity

Activity

4% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
4% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013
Evidence 8 Activity

Activity

8% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
8% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013
Evidence 9 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013
Evidence 10 Activity

Activity

5% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
5% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013
Evidence 11 Activity

Activity

10% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
10% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013
Evidence 12 Activity

Activity

18% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
18% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013