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Peptide record

TPDB06606

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06606
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIHHILKYGKPS
Physicochemical Analysis
C63H100N18O15
ARNDCEQMFTWV
GHIK
1349.60
10.20
4
0
4
+2
2.38
-0.492
97.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
110.40
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
2
H
2
I
1
L
2
K
0
M
0
F
1
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 2 I: 2 L: 1 K: 2 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C63H100N18O15
1349.60
10.20
+2
2.38
-0.492
Evidence Records 2 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and membrane-disruption mechanism of charge-enriched AMPs exhibiting cell selectivity, high-salt resistance, and anti-biofilm properties. | Amino Acids | 2016
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.26450121] 0% hemolysis at 50 µM , 0% hemolysis at 100 µM , 0% hemolysis at 200 µM , 0% hemolysis at 400 µM against human red blood cells | Cytotoxicity: [Ref.26450121] The cell survial rates of normal human keratinocytes (NHK) are 100%, 95.8%, 88.3%, 83.4%, 77.4% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50, 100 µM. Melittin, the control, induced 100% toxicity against NHKs at a concentration of

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2016 Feb 48(2):505-22. doi: 10.1007/s00726-015-2104-0.