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Peptide record

TPDB06586

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06586
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb PD_Hemolysis
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KRIVKLILKWLR
Physicochemical Analysis
C76H136N22O13
ANDCEQGHMFPSTY
LK
1566.06
12.43
5
0
7
+5
0.51
0.250
186.67
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
351.20
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
3
L
3
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 3 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
12
C76H136N22O13
1566.06
12.43
+5
0.51
0.250
Evidence Records 21 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

Escherichia coli KCTC 1682

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram- E. coli KCTC 1682 (MIC 4 uM), P. aeruginosa KCTC 1637 (MIC 8 uM), S. typhimurium KCTC 1926 (MIC 4 uM), Gram+ B. subtil
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

Pseudomonas aeruginosa KCTC 1637

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli KCTC 1682 (MIC 4 uM), P. aeruginosa KCTC 1637 (MIC 8 uM), S. typhimurium KCTC 1926 (MIC 4 uM), Gram+ B. subtilis KCTC 3068 (MIC 4 uM), S. epidermi
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

S. typhimurium KCTC 1926

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli KCTC 1682 (MIC 4 uM), P. aeruginosa KCTC 1637 (MIC 8 uM), S. typhimurium KCTC 1926 (MIC 4 uM), Gram+ B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 1 uM), and S. aure
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µM

Target

B. subtilis KCTC 3068

Source & Reference

dbAMP DRAMP

Other

MIC 4 uM), P. aeruginosa KCTC 1637 (MIC 8 uM), S. typhimurium KCTC 1926 (MIC 4 uM), Gram+ B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 1 uM), and S. aureus KCTC 1621 (MIC 4 uM). Warning: Nonsta
Evidence 5 Activity

Activity

MIC
Antibacterial
1 µM

Target

Staphylococcus epidermidis KCTC 1917

Source & Reference

dbAMP DRAMP

Other

(MIC 8 uM), S. typhimurium KCTC 1926 (MIC 4 uM), Gram+ B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 1 uM), and S. aureus KCTC 1621 (MIC 4 uM). Warning: Nonstandard assays. The peptide can also bi
Evidence 6 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus KCTC 1621

Source & Reference

dbAMP DRAMP

Other

C 4 uM), Gram+ B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 1 uM), and S. aureus KCTC 1621 (MIC 4 uM). Warning: Nonstandard assays. The peptide can also bind to LPS and show an anti-inflammat
Evidence 7 Activity

Activity

MIC
Antifungal
4 µM

Target

Escherichia coli KCTC 1682

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against Gram- E. coli KCTC 1682 (MIC 4 uM), P. aeruginosa KCTC 1637 (MIC 8 uM), S. typhimurium KCTC 1926 (MIC 4 uM), Gram+ B. subtil
Evidence 8 Activity

Activity

MIC
Antifungal
8 µM

Target

Pseudomonas aeruginosa KCTC 1637

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against Gram- E. coli KCTC 1682 (MIC 4 uM), P. aeruginosa KCTC 1637 (MIC 8 uM), S. typhimurium KCTC 1926 (MIC 4 uM), Gram+ B. subtilis KCTC 3068 (MIC 4 uM), S. epidermi
Evidence 9 Activity

Activity

MIC
Antifungal
4 µM

Target

S. typhimurium KCTC 1926

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against Gram- E. coli KCTC 1682 (MIC 4 uM), P. aeruginosa KCTC 1637 (MIC 8 uM), S. typhimurium KCTC 1926 (MIC 4 uM), Gram+ B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 1 uM), and S. aure
Evidence 10 Activity

Activity

MIC
Antifungal
4 µM

Target

B. subtilis KCTC 3068

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

MIC 4 uM), P. aeruginosa KCTC 1637 (MIC 8 uM), S. typhimurium KCTC 1926 (MIC 4 uM), Gram+ B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 1 uM), and S. aureus KCTC 1621 (MIC 4 uM). Warning: Nonsta
Evidence 11 Activity

Activity

MIC
Antifungal
1 µM

Target

Staphylococcus epidermidis KCTC 1917

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 8 uM), S. typhimurium KCTC 1926 (MIC 4 uM), Gram+ B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 1 uM), and S. aureus KCTC 1621 (MIC 4 uM). Warning: Nonstandard assays. The peptide can also bi
Evidence 12 Activity

Activity

MIC
Antifungal
4 µM

Target

Staphylococcus aureus KCTC 1621

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 4 uM), Gram+ B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 1 uM), and S. aureus KCTC 1621 (MIC 4 uM). Warning: Nonstandard assays. The peptide can also bind to LPS and show an anti-inflammat
Evidence 13 Activity

Activity

MHC10
Hemolysis
25 µM
[Ref.28525841] MHC10=25 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Eur J Med Chem. 2017 Aug 18 136:428-441. doi: 10.1016/j.ejmech.2017.05.028.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 14 Activity

Activity

HC50
Hemolysis
96 µM
[Ref.24105706] HC50=96 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
J Pept Sci. 2013 Nov 19(11):700-7. doi: 10.1002/psc.2552.
Evidence 15 Activity

Activity

50% Hemolysis
Toxicity
96 µM
Hemolytic Cytotoxic
50% Hemolysis | 96 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity. | J Pept Sci | 2013
Evidence 16 Activity

Activity

10% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
10% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
LL-37-derived short antimicrobial peptide KR-12-a5 and its d-amino acid substituted analogs with cell selectivity, anti-biofilm activity, synergistic effect with conventional antibiotics, and anti-inflammatory activity. | Eur J Med Chem | 2017
Evidence 17 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
LL-37-derived short antimicrobial peptide KR-12-a5 and its d-amino acid substituted analogs with cell selectivity, anti-biofilm activity, synergistic effect with conventional antibiotics, and anti-inflammatory activity. | Eur J Med Chem | 2017
Evidence 18 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28525841] MHC10=25 µM against human red blood cells | Cytotoxicity: [Ref.28525841] The cell viability of mouse macrophage RAW264.7 cells is 100%, 116.6%, 112.1%, 115.1%, 112.8%, 106.8% and 108.3% at peptide concentrations of 0, 4, 8, 16, 32, 64, 128 and 256 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Med Chem. 2017 Aug 18 136:428-441. doi: 10.1016/j.ejmech.2017.05.028.
Evidence 19 Activity

Activity

HC50
Toxicity
96 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.24105706] HC50=96 µM against human red blood cells | Cytotoxicity: [Ref.24105706] The cell viability of RAW264.7 macrophage cells is 96.6%, 100.1%, 96.6%, 96.8%, 81.2%, 3.1%, 0% and 0% at peptide concentrations of 0.78, 1.56, 3.12, 6.25, 12.5, 25, 50 and 100 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2013 Nov 19(11):700-7. doi: 10.1002/psc.2552.
Evidence 20 Hemolysis

Activity

25 µM
MHC10
[Ref.28525841] MHC10=25 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

PD_Hemolysis
Eur J Med Chem. 2017 Aug 18 136:428-441. doi: 10.1016/j.ejmech.2017.05.028.
DRAMP4
PD_Hemolysis
Evidence 21 Hemolysis

Activity

96 µM
HC50
[Ref.24105706] HC50=96 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

PD_Hemolysis
J Pept Sci. 2013 Nov 19(11):700-7. doi: 10.1002/psc.2552.
DRAMP4
PD_Hemolysis