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Peptide record

TPDB06576

Antibacterial Toxicity standard

12 amino acids

3D PDB MODEL

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TPDB ID TPDB06576

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

YYHFWHRGVTKR

FASTA

>TPDB06576|Antibacterial;Toxicity|length=12
YYHFWHRGVTKR

Formula C79H108N24O16

Absent Amino Acids ANDCEQILMPS

Common Amino Acids RHY

Mass 1649.88

PI 10.59

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +3

Boman Index -0.11

Hydrophobicity -1.408

Aliphatic Index 24.17

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 8480

Absorbance 280nm 513.98

Polar Residues 3

number

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 2 I: 0 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 1 W: 1 Y: 2 V: 1

Length

Formula

C79H108N24O16

Mass

1649.88

10.59

Net Charge

Boman Index

-0.11

Hydrophobicity

-1.408

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 40 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 40 uM), P. aeruginosa (MIC 40 uM) S. enterica (MIC 40 uM) K. pneumoniae (MIC 40 uM) S. aureus

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 40 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 40 uM), P. aeruginosa (MIC 40 uM) S. enterica (MIC 40 uM) K. pneumoniae (MIC 40 uM) S. aureus (MIC 40 uM) B. subtilis (

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 40 µM

Target

Target Organism S. enterica

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 40 uM), P. aeruginosa (MIC 40 uM) S. enterica (MIC 40 uM) K. pneumoniae (MIC 40 uM) S. aureus (MIC 40 uM) B. subtilis (MIC 30 uM) S.pyogenes (M

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 40 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 40 uM), P. aeruginosa (MIC 40 uM) S. enterica (MIC 40 uM) K. pneumoniae (MIC 40 uM) S. aureus (MIC 40 uM) B. subtilis (MIC 30 uM) S.pyogenes (MIC 70 uM) and E. faecalis

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 40 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

IC 40 uM), P. aeruginosa (MIC 40 uM) S. enterica (MIC 40 uM) K. pneumoniae (MIC 40 uM) S. aureus (MIC 40 uM) B. subtilis (MIC 30 uM) S.pyogenes (MIC 70 uM) and E. faecalis (MIC 30 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source NA

Other

Evidence Text

a (MIC 40 uM) S. enterica (MIC 40 uM) K. pneumoniae (MIC 40 uM) S. aureus (MIC 40 uM) B. subtilis (MIC 30 uM) S.pyogenes (MIC 70 uM) and E. faecalis (MIC 30 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 70 µM

Target

Target Organism S.pyogenes

Source & Reference

Database Source NA

Other

Evidence Text

a (MIC 40 uM) K. pneumoniae (MIC 40 uM) S. aureus (MIC 40 uM) B. subtilis (MIC 30 uM) S.pyogenes (MIC 70 uM) and E. faecalis (MIC 30 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30 µM

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 40 uM) S. aureus (MIC 40 uM) B. subtilis (MIC 30 uM) S.pyogenes (MIC 70 uM) and E. faecalis (MIC 30 uM).

Evidence 9 Activity

Activity

Activity Endpoint <5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 150 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

<5% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Cell-Selective Pore Forming Antimicrobial Peptides of the Prodomain of Human Furin: A Conserved Aromatic/Cationic Sequence Mapping, Membrane Disruption, and Atomic-Resolution Structure and Dynamics. | ACS Omega | 2018