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Peptide record

TPDB06560

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06560
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
VQWRIRVAVIRK
Physicochemical Analysis
C70H122N24O14
NDCEGHLMFPSTY
RV
1523.89
12.71
4
0
7
+4
1.57
0.133
145.83
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
5500
360.92
1
Residue Composition
number
1
A
3
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
2
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 3
Chemical Descriptors
12
C70H122N24O14
1523.89
12.71
+4
1.57
0.133
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

NA

Other

Active against S. aureus ATCC 25923 (MIC 16 ug/ml), E. coli ATCC 25922 (MIC 16 ug/ml), P. aeruginosa PAO1 (MIC 16 ug/ml), and S. enterica se
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

Active against S. aureus ATCC 25923 (MIC 16 ug/ml), E. coli ATCC 25922 (MIC 16 ug/ml), P. aeruginosa PAO1 (MIC 16 ug/ml), and S. enterica serovar Typhi (MIC 8 ug/ml). Antibiof
Evidence 3 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Pseudomonas aeruginosa PAO1

Source & Reference

NA

Other

Active against S. aureus ATCC 25923 (MIC 16 ug/ml), E. coli ATCC 25922 (MIC 16 ug/ml), P. aeruginosa PAO1 (MIC 16 ug/ml), and S. enterica serovar Typhi (MIC 8 ug/ml). Antibiofilm:bacteria:P. gingivalis and inhi
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

S. enterica serovar Typhi

Source & Reference

NA

Other

(MIC 16 ug/ml), E. coli ATCC 25922 (MIC 16 ug/ml), P. aeruginosa PAO1 (MIC 16 ug/ml), and S. enterica serovar Typhi (MIC 8 ug/ml). Antibiofilm:bacteria:P. gingivalis and inhibited virulence factor genes (antivirulence:b
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
>1280 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >1280 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In vitro and in vivo activities of antimicrobial peptides developed using an amino acid-based activity prediction method. | Antimicrob Agents Chemother | 2014
Evidence 6 Activity

Activity

LC50
Toxicity
>64 µg/mL
Cytotoxic
LC50 | >64 | µg/mL | target cell: Human periodontal ligament cells

Target

Human periodontal ligament cells

Source & Reference

NA
DBAASP
Antibacterial and Antibiofilm Activities of Novel Antimicrobial Peptide DP7 against the Periodontal Pathogen Porphyromonas gingivalis. | J Appl Microbiol | 2022