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Peptide record

TPDB06537

Antibacterial Hemolysis Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06537
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia PD_Hemolysis
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LRIVKLILKWLR
Physicochemical Analysis
C76H135N21O13
ANDCEQGHMFPSTY
L
1551.04
12.42
4
0
8
+4
-1.04
0.892
219.17
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
354.60
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
4
L
2
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 4 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
12
C76H135N21O13
1551.04
12.42
+4
-1.04
0.892
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
16 µM

Target

Escherichia coli KCTC 1682

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram- E. coli KCTC 1682 (MIC 16 uM), P. aeruginosa KCTC 1637 (MIC 16 uM), S. typhimurium KCTC 1926 (MIC 4 uM), Gram+ B. subti
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µM

Target

Pseudomonas aeruginosa KCTC 1637

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli KCTC 1682 (MIC 16 uM), P. aeruginosa KCTC 1637 (MIC 16 uM), S. typhimurium KCTC 1926 (MIC 4 uM), Gram+ B. subtilis KCTC 3068 (MIC 8 uM), S. epidermi
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

S. typhimurium KCTC 1926

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli KCTC 1682 (MIC 16 uM), P. aeruginosa KCTC 1637 (MIC 16 uM), S. typhimurium KCTC 1926 (MIC 4 uM), Gram+ B. subtilis KCTC 3068 (MIC 8 uM), S. epidermidis KCTC 1917 (MIC 2 uM), and S. aure
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µM

Target

B. subtilis KCTC 3068

Source & Reference

dbAMP DRAMP

Other

C 16 uM), P. aeruginosa KCTC 1637 (MIC 16 uM), S. typhimurium KCTC 1926 (MIC 4 uM), Gram+ B. subtilis KCTC 3068 (MIC 8 uM), S. epidermidis KCTC 1917 (MIC 2 uM), and S. aureus KCTC 1621 (MIC 4 uM). Warning: Nonsta
Evidence 5 Activity

Activity

MIC
Antibacterial
2 µM

Target

Staphylococcus epidermidis KCTC 1917

Source & Reference

dbAMP DRAMP

Other

(MIC 16 uM), S. typhimurium KCTC 1926 (MIC 4 uM), Gram+ B. subtilis KCTC 3068 (MIC 8 uM), S. epidermidis KCTC 1917 (MIC 2 uM), and S. aureus KCTC 1621 (MIC 4 uM). Warning: Nonstandard assays. The peptide can also bi
Evidence 6 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus KCTC 1621

Source & Reference

dbAMP DRAMP

Other

C 4 uM), Gram+ B. subtilis KCTC 3068 (MIC 8 uM), S. epidermidis KCTC 1917 (MIC 2 uM), and S. aureus KCTC 1621 (MIC 4 uM). Warning: Nonstandard assays. The peptide can also bind to LPS and show an anti-inflammat
Evidence 7 Activity

Activity

HC50
Hemolysis
22 µM
[Ref.24105706] HC50=22 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
J Pept Sci. 2013 Nov 19(11):700-7. doi: 10.1002/psc.2552.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
22 µM
Hemolytic Cytotoxic
50% Hemolysis | 22 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity. | J Pept Sci | 2013
Evidence 9 Activity

Activity

HC50
Toxicity
22 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.24105706] HC50=22 µM against human red blood cells | Cytotoxicity: [Ref.24105706] The cell viability of RAW264.7 macrophage cells is 100%, 99.1%, 100%, 98.8%, 99.9%, 85.3%, 5.9% and 0% at peptide concentrations of 0.78, 1.56, 3.12, 6.25, 12.5, 25, 50 and 100 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2013 Nov 19(11):700-7. doi: 10.1002/psc.2552.
Evidence 10 Hemolysis

Activity

22 µM
HC50
[Ref.24105706] HC50=22 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

PD_Hemolysis
J Pept Sci. 2013 Nov 19(11):700-7. doi: 10.1002/psc.2552.
DRAMP4
PD_Hemolysis