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Peptide record

TPDB06525

Antibacterial Toxicity standard

12 amino acids

3D PDB MODEL

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TPDB ID TPDB06525

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

GIRRILRYGRRS

FASTA

>TPDB06525|Antibacterial;Toxicity|length=12
GIRRILRYGRRS

Formula C64H115N27O15

Absent Amino Acids ANDCEQHKMFPTWV

Common Amino Acids R

Mass 1502.79

PI 12.58

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +5

Boman Index 2.08

Hydrophobicity -1.050

Aliphatic Index 97.50

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 99.15

Polar Residues 2

number

Amino Acid Distribution

A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 1 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0

Length

Formula

C64H115N27O15

Mass

1502.79

12.58

Net Charge

Boman Index

2.08

Hydrophobicity

-1.050

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3 µM

Target

Target Organism Escherichia coli ATCC 11219

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli ATCC 11219 (MIC 3 uM), P. aeruginosa ATCC 13388 (MIC 20 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 10

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 20 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 13388

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli ATCC 11219 (MIC 3 uM), P. aeruginosa ATCC 13388 (MIC 20 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 10 uM), K. pneumoniae ATCC 10031 (MIC 5

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µM

Target

Target Organism S. enterica serovar Typhimurium ATCC 14028

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli ATCC 11219 (MIC 3 uM), P. aeruginosa ATCC 13388 (MIC 20 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 10 uM), K. pneumoniae ATCC 10031 (MIC 5 uM), S. aureus ATCC 6538 (MIC 10 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5 µM

Target

Target Organism Klebsiella pneumoniae ATCC 10031

Source & Reference

Database Source NA

Other

Evidence Text

eruginosa ATCC 13388 (MIC 20 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 10 uM), K. pneumoniae ATCC 10031 (MIC 5 uM), S. aureus ATCC 6538 (MIC 10 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µM

Target

Target Organism Staphylococcus aureus ATCC 6538

Source & Reference

Database Source NA

Other

Evidence Text

enterica serovar Typhimurium ATCC 14028 (MIC 10 uM), K. pneumoniae ATCC 10031 (MIC 5 uM), S. aureus ATCC 6538 (MIC 10 uM).

Evidence 6 Activity

Activity

Activity Endpoint 1% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 20 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

1% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013

Evidence 7 Activity

Activity

Activity Endpoint 6% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

6% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013

Evidence 8 Activity

Activity

Activity Endpoint 12% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

12% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013

Evidence 9 Activity

Activity

Activity Endpoint 22% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

22% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013

Evidence 10 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

- | NA | target cell: Vero cells

Target

Target Cell Vero cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013