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Peptide record

TPDB06501

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06501
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIRDILKYGKPS
Physicochemical Analysis
C61H103N17O17
ANCEQHMFTWV
GIK
1346.59
10.19
3
1
4
+2
2.50
-0.625
97.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
110.65
2
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
0
E
0
Q
2
G
0
H
2
I
1
L
2
K
0
M
0
F
1
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 1 K: 2 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C61H103N17O17
1346.59
10.19
+2
2.50
-0.625
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5 µM

Target

Escherichia coli ATCC 11219

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E. coli ATCC 11219 (MIC 5 uM), P. aeruginosa ATCC 13388 (MIC 20 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 5
Evidence 2 Activity

Activity

MIC
Antibacterial
20 µM

Target

Pseudomonas aeruginosa ATCC 13388

Source & Reference

dbAMP DRAMP

Other

active against E. coli ATCC 11219 (MIC 5 uM), P. aeruginosa ATCC 13388 (MIC 20 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 5 uM), K. pneumoniae ATCC 10031 (MIC 5 u
Evidence 3 Activity

Activity

MIC
Antibacterial
5 µM

Target

S. enterica serovar Typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP

Other

active against E. coli ATCC 11219 (MIC 5 uM), P. aeruginosa ATCC 13388 (MIC 20 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 5 uM), K. pneumoniae ATCC 10031 (MIC 5 uM), S. aureus ATCC 6538 (MIC 10 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
5 µM

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

dbAMP DRAMP

Other

aeruginosa ATCC 13388 (MIC 20 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 5 uM), K. pneumoniae ATCC 10031 (MIC 5 uM), S. aureus ATCC 6538 (MIC 10 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
10 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

dbAMP DRAMP

Other

enterica serovar Typhimurium ATCC 14028 (MIC 5 uM), K. pneumoniae ATCC 10031 (MIC 5 uM), S. aureus ATCC 6538 (MIC 10 uM).
Evidence 6 Activity

Activity

1% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
1% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013
Evidence 7 Activity

Activity

5% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
5% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013
Evidence 8 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013
Evidence 9 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic
Hemolytic_activity: [Ref.24957834] Some peptides at 50 µM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 µM and 200 µM peptide.

Target

erythrocytes

Source & Reference

NA
DRAMP
Antimicrob Agents Chemother. 2014 Sep 58(9):5280-90.