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Peptide record

TPDB06500

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06500
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIHDILKYGKPA
Physicochemical Analysis
C61H98N16O16
RNCEQMFSTWV
GIK
1311.55
9.65
3
1
5
+1
2.35
-0.300
105.83
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
113.61
1
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
2
G
1
H
2
I
1
L
2
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 2 L: 1 K: 2 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C61H98N16O16
1311.55
9.65
+1
2.35
-0.300
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
30 µM

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
ruginosa ATCC 13388 (MIC >50 uM), S-enterica serovar Typhimurium ATCC 14028 (MIC >50 uM), K. pneumoniae ATCC 10031 (MIC 30 uM), S-aureus ATCC 6538 (MIC >50 uM).
Evidence 2 Activity

Activity

2% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
2% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural insights into and activity analysis of the antimicrobial peptide myxinidin. | Antimicrob Agents Chemother | 2014
Evidence 3 Activity

Activity

20% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
20% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural insights into and activity analysis of the antimicrobial peptide myxinidin. | Antimicrob Agents Chemother | 2014
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.24957834] Some peptides at 50 µM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 µM and 200 µM peptide. | Cytotoxicity: [Ref.24957834] The toxicity of the peptide against Vero cells is 0.7%, 0.7%, 7%, 14.9% and 19.9% at peptide concentrations of 1, 20, 50, 100 and 200 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Antimicrob Agents Chemother. 2014 Sep 58(9):5280-90.