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Peptide record

TPDB06496

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB06496
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
KRRWPWWPWRLI
Physicochemical Analysis
C90H126N26O13
ANDCEQGHMFSTYV
W
1780.16
12.71
4
0
6
+4
-3.95
-1.325
65.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
22000
1235.85
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
1
K
0
M
0
F
2
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 2 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
12
C90H126N26O13
1780.16
12.71
+4
-3.95
-1.325
Evidence Records 31 records
Evidence 1 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Enterococcus faecalis PCM 2673

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against Gram+ E. faecalis PCM 2673 (MIC 16 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 8 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Staphylococcus aureus ATCC 25923 or 9144

Source & Reference

dbAMP

Other

active against Gram+ E. faecalis PCM 2673 (MIC 16 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 8 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 4-8 ug/ml
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

S. pneumoniae ATCC 49619

Source & Reference

dbAMP

Other

st Gram+ E. faecalis PCM 2673 (MIC 16 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 8 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 4-8 ug/ml), K. pneumoniae ATCC 700603 (MIC 4 ug/m
Evidence 4 Activity

Activity

MIC
Antibacterial
4-8 µg/mL

Target

Escherichia coli ATCC 25922 or 23506

Source & Reference

dbAMP

Other

S. aureus ATCC 25923 or 9144 (MIC 8 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 4-8 ug/ml), K. pneumoniae ATCC 700603 (MIC 4 ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), fungi A.
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP

Other

. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 4-8 ug/ml), K. pneumoniae ATCC 700603 (MIC 4 ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albic
Evidence 6 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

dbAMP

Other

am- E. coli ATCC 25922 or 23506 (MIC 4-8 ug/ml), K. pneumoniae ATCC 700603 (MIC 4 ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 32 ug/ml), and C. g
Evidence 7 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

A. niger ATCC 16404

Source & Reference

dbAMP

Other

l), K. pneumoniae ATCC 700603 (MIC 4 ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 32 ug/ml), and C. glabrata ATCC 15126 (MIC 64 ug/ml).
Evidence 8 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

C.albicans ATCC 10231

Source & Reference

dbAMP

Other

ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 32 ug/ml), and C. glabrata ATCC 15126 (MIC 64 ug/ml).
Evidence 9 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

C. glabrata ATCC 15126

Source & Reference

dbAMP

Other

/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 32 ug/ml), and C. glabrata ATCC 15126 (MIC 64 ug/ml).
Evidence 10 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Enterococcus faecalis PCM 2673

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against Gram+ E. faecalis PCM 2673 (MIC 16 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 8 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram
Evidence 11 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

Staphylococcus aureus ATCC 25923 or 9144

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against Gram+ E. faecalis PCM 2673 (MIC 16 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 8 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 4-8 ug/ml
Evidence 12 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

S. pneumoniae ATCC 49619

Source & Reference

dbAMP CAFPdb Antifungipept

Other

st Gram+ E. faecalis PCM 2673 (MIC 16 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 8 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 4-8 ug/ml), K. pneumoniae ATCC 700603 (MIC 4 ug/m
Evidence 13 Activity

Activity

MIC
Antifungal
4-8 µg/mL

Target

Escherichia coli ATCC 25922 or 23506

Source & Reference

dbAMP CAFPdb Antifungipept

Other

S. aureus ATCC 25923 or 9144 (MIC 8 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 4-8 ug/ml), K. pneumoniae ATCC 700603 (MIC 4 ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), fungi A.
Evidence 14 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP CAFPdb Antifungipept

Other

. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 4-8 ug/ml), K. pneumoniae ATCC 700603 (MIC 4 ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albic
Evidence 15 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

dbAMP CAFPdb Antifungipept

Other

am- E. coli ATCC 25922 or 23506 (MIC 4-8 ug/ml), K. pneumoniae ATCC 700603 (MIC 4 ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 32 ug/ml), and C. g
Evidence 16 Activity

Activity

MIC
Antifungal
64 µg/mL

Target

A. niger ATCC 16404

Source & Reference

dbAMP CAFPdb Antifungipept

Other

l), K. pneumoniae ATCC 700603 (MIC 4 ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 32 ug/ml), and C. glabrata ATCC 15126 (MIC 64 ug/ml).
Evidence 17 Activity

Activity

MIC
Antifungal
32 µg/mL

Target

C.albicans ATCC 10231

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 32 ug/ml), and C. glabrata ATCC 15126 (MIC 64 ug/ml).
Evidence 18 Activity

Activity

MIC
Antifungal
64 µg/mL

Target

C. glabrata ATCC 15126

Source & Reference

dbAMP CAFPdb Antifungipept

Other

/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 32 ug/ml), and C. glabrata ATCC 15126 (MIC 64 ug/ml).
Evidence 19 Activity

Activity

MIC
Antiparasitic
16 µg/mL

Target

Enterococcus faecalis PCM 2673

Source & Reference

NA

Other

active against Gram+ E. faecalis PCM 2673 (MIC 16 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 8 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram
Evidence 20 Activity

Activity

MIC
Antiparasitic
8 µg/mL

Target

Staphylococcus aureus ATCC 25923 or 9144

Source & Reference

NA

Other

active against Gram+ E. faecalis PCM 2673 (MIC 16 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 8 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 4-8 ug/ml
Evidence 21 Activity

Activity

MIC
Antiparasitic
8 µg/mL

Target

S. pneumoniae ATCC 49619

Source & Reference

NA

Other

st Gram+ E. faecalis PCM 2673 (MIC 16 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 8 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 4-8 ug/ml), K. pneumoniae ATCC 700603 (MIC 4 ug/m
Evidence 22 Activity

Activity

MIC
Antiparasitic
4-8 µg/mL

Target

Escherichia coli ATCC 25922 or 23506

Source & Reference

NA

Other

S. aureus ATCC 25923 or 9144 (MIC 8 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 4-8 ug/ml), K. pneumoniae ATCC 700603 (MIC 4 ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), fungi A.
Evidence 23 Activity

Activity

MIC
Antiparasitic
4 µg/mL

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

NA

Other

. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 4-8 ug/ml), K. pneumoniae ATCC 700603 (MIC 4 ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albic
Evidence 24 Activity

Activity

MIC
Antiparasitic
4 µg/mL

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

NA

Other

am- E. coli ATCC 25922 or 23506 (MIC 4-8 ug/ml), K. pneumoniae ATCC 700603 (MIC 4 ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 32 ug/ml), and C. g
Evidence 25 Activity

Activity

MIC
Antiparasitic
64 µg/mL

Target

A. niger ATCC 16404

Source & Reference

NA

Other

l), K. pneumoniae ATCC 700603 (MIC 4 ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 32 ug/ml), and C. glabrata ATCC 15126 (MIC 64 ug/ml).
Evidence 26 Activity

Activity

MIC
Antiparasitic
32 µg/mL

Target

C.albicans ATCC 10231

Source & Reference

NA

Other

ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 32 ug/ml), and C. glabrata ATCC 15126 (MIC 64 ug/ml).
Evidence 27 Activity

Activity

MIC
Antiparasitic
64 µg/mL

Target

C. glabrata ATCC 15126

Source & Reference

NA

Other

/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 32 ug/ml), and C. glabrata ATCC 15126 (MIC 64 ug/ml).
Evidence 28 Activity

Activity

0% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Retro analog concept: comparative study on physico-chemical and biological properties of selected antimicrobial peptides. | Amino Acids | 2017
Evidence 29 Activity

Activity

5% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Retro analog concept: comparative study on physico-chemical and biological properties of selected antimicrobial peptides. | Amino Acids | 2017
Evidence 30 Activity

Activity

15% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
15% Hemolysis | 512 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Retro analog concept: comparative study on physico-chemical and biological properties of selected antimicrobial peptides. | Amino Acids | 2017
Evidence 31 Activity

Activity

IC50
Toxicity
29.51 µg/mL
Cytotoxic
IC50 | 29.51 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Antimicrobial Activity of Selected Antimicrobial Peptides Against Planktonic Culture and Biofilm of Acinetobacter baumannii. | Probiotics Antimicrob Proteins | 2018