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Peptide record

TPDB06487

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06487
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KRIVQRIKDWLR
Physicochemical Analysis
C73H127N25O16
ANCEGHMFPSTY
R
1610.97
12.13
5
1
5
+4
3.26
-1.017
121.67
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
341.41
1
Residue Composition
number
0
A
3
R
0
N
1
D
0
C
0
E
1
Q
0
G
0
H
2
I
1
L
2
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 1 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
12
C73H127N25O16
1610.97
12.13
+4
3.26
-1.017
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µM

Target

Escherichia coli KCTC 1682

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram- E. coli KCTC 1682 (MIC 2 uM), P. aeruginosa KCTC 1637 (MIC 4 uM), S. typhimurium KCTC 1926 (MIC 2 uM), Gram+ B. subtil
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

Pseudomonas aeruginosa KCTC 1637

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli KCTC 1682 (MIC 2 uM), P. aeruginosa KCTC 1637 (MIC 4 uM), S. typhimurium KCTC 1926 (MIC 2 uM), Gram+ B. subtilis KCTC 3068 (MIC 8 uM), S. epidermi
Evidence 3 Activity

Activity

MIC
Antibacterial
2 µM

Target

S. typhimurium KCTC 1926

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli KCTC 1682 (MIC 2 uM), P. aeruginosa KCTC 1637 (MIC 4 uM), S. typhimurium KCTC 1926 (MIC 2 uM), Gram+ B. subtilis KCTC 3068 (MIC 8 uM), S. epidermidis KCTC 1917 (MIC 1 uM), and S. aure
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µM

Target

B. subtilis KCTC 3068

Source & Reference

dbAMP DRAMP

Other

MIC 2 uM), P. aeruginosa KCTC 1637 (MIC 4 uM), S. typhimurium KCTC 1926 (MIC 2 uM), Gram+ B. subtilis KCTC 3068 (MIC 8 uM), S. epidermidis KCTC 1917 (MIC 1 uM), and S. aureus KCTC 1621 (MIC 4 uM). Warning: Nonsta
Evidence 5 Activity

Activity

MIC
Antibacterial
1 µM

Target

Staphylococcus epidermidis KCTC 1917

Source & Reference

dbAMP DRAMP

Other

(MIC 4 uM), S. typhimurium KCTC 1926 (MIC 2 uM), Gram+ B. subtilis KCTC 3068 (MIC 8 uM), S. epidermidis KCTC 1917 (MIC 1 uM), and S. aureus KCTC 1621 (MIC 4 uM). Warning: Nonstandard assays.
Evidence 6 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus KCTC 1621

Source & Reference

dbAMP DRAMP

Other

C 2 uM), Gram+ B. subtilis KCTC 3068 (MIC 8 uM), S. epidermidis KCTC 1917 (MIC 1 uM), and S. aureus KCTC 1621 (MIC 4 uM). Warning: Nonstandard assays.
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
>800 µM
Hemolytic Cytotoxic
50% Hemolysis | >800 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity. | J Pept Sci | 2013
Evidence 8 Activity

Activity

HC50
Toxicity
800 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.24105706] HC50>800 µM against human red blood cells | Cytotoxicity: [Ref.24105706] The cell viability of RAW264.7 macrophage cells is 108.7%, 111.2%, 107.5%, 107.5%, 103.1%, 111.2%, 107.2%, 98.1% at peptide concentrations of 0.78, 1.56, 3.12, 6.25, 12.5, 25, 50 and 100 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2013 Nov 19(11):700-7. doi: 10.1002/psc.2552.