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Peptide record

TPDB06460

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06460
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IHKFWRRWFKHI
Physicochemical Analysis
C88H124N26O13
ANDCEQGLMPSTYV
RHIKFW
1754.12
12.42
6
0
6
+4
-1.06
-0.867
65.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
11000
627.10
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
2
H
2
I
0
L
2
K
0
M
2
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 2 I: 2 L: 0 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
12
C88H124N26O13
1754.12
12.42
+4
-1.06
-0.867
Evidence Records 2 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
5% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short Symmetric-End Antimicrobial Peptides Centered on ?-Turn Amino Acids Unit Improve Selectivity and Stability. | Front Microbiol | 2018
Evidence 2 Activity

Activity

MHC
Toxicity
128 µM
Hemolytic
Hemolytic_activity: [Ref.30538681] MHC>128µM against human blood cells.The minimum hemolytic concentration (MHC) is defined as the peptide concentration resulting in 5% hemolysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Microbiol. 2018 9: 2832. Published online 2018 Nov 27. doi: 10.3389/fmicb.2018.02832