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Peptide record

TPDB06411

Antibacterial Anticancer Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB06411
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RRWTWWWTWRR
Physicochemical Analysis
C87H114N28O14
ANDCEQGHILKMFPSYV
W
1776.04
12.88
4
0
5
+4
-5.73
-2.173
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
27500
1548.39
2
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
2
T
5
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 2 W: 5 Y: 0 V: 0
Chemical Descriptors
11
C87H114N28O14
1776.04
12.88
+4
-5.73
-2.173
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µM

Target

Escherichia coli 25922 or UB1005

Source & Reference

NA

Other

active against E. coli 25922 or UB1005 (MIC 2 uM), P. aeruginosa 27853 (MIC 4 uM), S. epidermidis 12228 (MIC 2 uM), S. aureus 29213 or MRSA
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

Pseudomonas aeruginosa 27853

Source & Reference

NA

Other

active against E. coli 25922 or UB1005 (MIC 2 uM), P. aeruginosa 27853 (MIC 4 uM), S. epidermidis 12228 (MIC 2 uM), S. aureus 29213 or MRSA43300 (MIC 2-4 uM), L.rhamnosus
Evidence 3 Activity

Activity

MIC
Antibacterial
2 µM

Target

Staphylococcus epidermidis 12228

Source & Reference

NA

Other

active against E. coli 25922 or UB1005 (MIC 2 uM), P. aeruginosa 27853 (MIC 4 uM), S. epidermidis 12228 (MIC 2 uM), S. aureus 29213 or MRSA43300 (MIC 2-4 uM), L.rhamnosus 1.0385 (MIC 128 uM), L.plantarum
Evidence 4 Activity

Activity

MIC
Antibacterial
2-4 µM

Target

Staphylococcus aureus 29213 or MRSA43300

Source & Reference

NA

Other

22 or UB1005 (MIC 2 uM), P. aeruginosa 27853 (MIC 4 uM), S. epidermidis 12228 (MIC 2 uM), S. aureus 29213 or MRSA43300 (MIC 2-4 uM), L.rhamnosus 1.0385 (MIC 128 uM), L.plantarum 7469 (MIC 128 uM), C. albicans cgmcc 2.2086
Evidence 5 Activity

Activity

MIC
Antibacterial
128 µM

Target

L.plantarum 7469

Source & Reference

NA

Other

8 (MIC 2 uM), S. aureus 29213 or MRSA43300 (MIC 2-4 uM), L.rhamnosus 1.0385 (MIC 128 uM), L.plantarum 7469 (MIC 128 uM), C. albicans cgmcc 2.2086 (MIC 8 uM), C. parapsilosis CGMCC 2.3989 (MIC 16 uM).
Evidence 6 Activity

Activity

5% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
5% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptides With Triplet-Tryptophan-Pivot Promoted Pathogenic Bacteria Membrane Defects. | Front Microbiol | 2020
Evidence 7 Activity

Activity

25% Killing
Toxicity
64 µM
Cytotoxic
25% Killing | 64 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Peptides With Triplet-Tryptophan-Pivot Promoted Pathogenic Bacteria Membrane Defects. | Front Microbiol | 2020