Back to search

Peptide record

TPDB06405

HIV TAT 47–57 HIV-1 TAT HIV-PTD HIV-TAT P42-TAT PTD PTD (Tat) TAT Tat (47-57) TAT (PTD) TAT (Tatibody) Tat peptide TAT(47-57) Tat-A86 Tat-AIE dots TAT-gelonin Tat-GFP TAT-PTD Tat47–57 TAT₄₇₋₅₇ YG-Tat TAT1 Antibacterial Anticancer Antifungal Blood-Brain Barrier Cell-penetrating Peptides Toxicity Tumor-homing Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB06405
HIV TAT 47–57 HIV-1 TAT HIV-PTD HIV-TAT P42-TAT PTD PTD (Tat) TAT Tat (47-57) TAT (PTD) TAT (Tatibody) Tat peptide TAT(47-57) Tat-A86 Tat-AIE dots TAT-gelonin Tat-GFP TAT-PTD Tat47–57 TAT₄₇₋₅₇ YG-Tat TAT1
Antibacterial Anticancer Antifungal Blood-Brain Barrier Cell-penetrating Peptides Toxicity Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CancerPPD 2.0 SATPdb dbACP CAFPdb B3Pred BBPpredict CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP TumorHoPe2.0
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
YGRKKRRQRRR
Physicochemical Analysis
C64H118N32O14
ANDCEHILMFPSTWV
R
1559.85
12.71
8
0
1
+8
6.49
-3.636
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
95.52
2
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
11
C64H118N32O14
1559.85
12.71
+8
6.49
-3.636
Free
L
Linear
Amphipathic Cationic
Linear
Linear Cyclic
Free
Antimicrobial
Synthetic
Similarity
TyrGlyArgLysLysArgArgGlnArgArgArg
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)O N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O N[C@@H](CCCCN)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(C)C)C1OO1 N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)O N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)O NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N.C(CS)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)O N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)O N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)O N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)O N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)O NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)O NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 82 records
Evidence 1 Activity

Activity

at 1 µM 90-100% viablity
Anticancer

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

MTT/MTS assay
6-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2003

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

at 10 µM 80% viablity
Anticancer

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

MTT/MTS assay
6-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2003
Evidence 3 Activity

Activity

at 100 µM 60% viablity
Anticancer

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

MTT/MTS assay
6-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2003
Evidence 4 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source

Source & Reference

NA
B3Pdb
Evidence 5 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source

Source & Reference

NA
B3Pdb
Evidence 6 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 and C6 cells

Assay & Model

Male SCID mice
Male SCID mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
TPETPAFN and TPAFN
Cytoplasm
In vitro and in vivo
CCTTSSCCCCC
Evidence 7 Activity

Activity

Cell-penetrating Peptides

Target

PC-3 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
Protein (eGFP)
Unable to penetrate PC-3 cells at 5 mM concentartion
Endocytic pathway
In vitro
CCTTSSCCCCC
Evidence 8 Activity

Activity

Cell-penetrating Peptides

Target

KB cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
Small molecule drug (Doxorubicin and Paclitaxel)
Free
High
In vitro
CCTTSSCCCCC
Evidence 9 Activity

Activity

Cell-penetrating Peptides

Target

LS174T and HCT116, MDCK and 293 HEK

Assay & Model

C57BL/6 mice
C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Protein (gelonin)
Strong fluorescence signal was observed inside the cells incubated with TAT-gelonin, indicating rapid and efficient transduction of TAT-gelonin mediated by TAT
Fluid phase pinocytosis
In vitro and in vivo
CCTTSSCCCCC
Evidence 10 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Assay & Model

C57BL/6 mice, R6/2 transgenic and wild-type mice
C57BL/6 mice, R6/2 transgenic and wild-type mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
P42-TAT incorporated in a water-in-oil microemulsion
Cytoplasm and Nucelus
Higher uptake efficiency
In vitro and in vivo
CCTTSSCCCCC
Evidence 11 Activity

Activity

Cell-penetrating Peptides

Target

CT26 mouse colon cancer cells, HeLa and Hep3B cells

Assay & Model

Male Balb/c mice
Male Balb/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Peptide (Mitochondrial Target Domain of NOXA)
Lower uptake efficiency
In vitro and in vivo
CCTTSSCCCCC
Evidence 12 Activity

Activity

Cell-penetrating Peptides

Target

H9C2 cells, NIH 3T3 cells, Huh7 and A549

Assay & Model

BALB/c mice
BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Nucleic acid (siRNA)
Cytoplasm
In vitro and in vivo
CCTTSSCCCCC
Evidence 13 Activity

Activity

Cell-penetrating Peptides

Target

PC12 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Nanoparticle (Quantum dots)
Cytoplasm
Endocytic pathways
In vitro
CCTTSSCCCCC
Evidence 14 Activity

Activity

Cell-penetrating Peptides

Target

HeLa cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
FAM-labelled
Cytosol
TAT a 1-fold increase in permeability efficiency over RWRWR
In vitro
CCTTSSCCCCC
Evidence 15 Activity

Activity

Cell-penetrating Peptides

Target

Skin Fibroblast From Pa Patients

Assay & Model

A138T mouse model
A138T mouse model

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
FITC dye and Propionyl Coenzyme A Carboxylase (PCC)
Mitochondria
In vitro and in vivo
CCTTSSCCCCC
Evidence 16 Activity

Activity

Cell-penetrating Peptides

Target

A549, HeLa, Hepg2 And MCF-7 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
FITC-labeled PEG-PCL micelles
Cytoplasm
The micelles PSPT-90 displayed 4 to 6 fold higher overall MFI compared to non conjugated PSPT-0.
Energy-dependent and energy-independent pathways
In vitro
CCTTSSCCCCC
Evidence 17 Activity

Activity

Cell-penetrating Peptides

Target

SH-SY5Y Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Genes encoding LepHO and LepFNR
Cytoplasm
TAT-LepFNR permanence inside the cell is shorter compared to TAT-LepHO.
Endocytosis
In vitro
CCTTSSCCCCC
Evidence 18 Activity

Activity

Cell-penetrating Peptides

Target

HeLa And Opm-2 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
FAM-labelled
Cytoplasm
TAT and ARG demonstrated higher permeability efficiencies compared to OWRWR and RWRWR
In vitro
CCTTSSCCCCC
Evidence 19 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7, HeLa, Hepg2 And MCF-7/Adr Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
Cytoplasm
Penetrating capacity of PFV and VPT were much lower than TAT while it was higher for CsA.
Endocytosis
In vitro
CCTTSSCCCCC
Evidence 20 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Mice (Kunming species, 22 g, sex-matched)
Mice (Kunming species, 22 g, sex-matched)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
Gamma-aminobutyric acid (GABA)
In vivo
CCTTSSCCCCC
Evidence 21 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Female Balb/c mice (6–8 week) infected with MTB.
Female Balb/c mice (6–8 week) infected with MTB.

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
Ag85B gene product
Higher Ig2a was found in TAT-Ag85B group than only Ag85B vaccination
In vivo
CCTTSSCCCCC
Evidence 22 Activity

Activity

Cell-penetrating Peptides

Target

Cd4+ T Cells

Assay & Model

Male C57BL/6 (MHC haplo- type H-2b age, 6-8 weeks weight, 20±2 g) mice
Male C57BL/6 (MHC haplo- type H-2b age, 6-8 weeks weight, 20±2 g) mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
Mouse Forkhead box P3 (mFOXP3) transcritpion factor
In vitro and in vivo
CCTTSSCCCCC
Evidence 23 Activity

Activity

Cell-penetrating Peptides

Target

HeLa , Mat-Lylu Cells , Sw480, Hek293T, HUVEC And Hbl100 Cell Lines

Assay & Model

Healthy female 4 to 6 week-old BALB/c mice
Healthy female 4 to 6 week-old BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
Gold nanoparticles (NRs)
Cytoplasm
Lycosin-I and TAT showed comparable intracellular internalization with an increase at least 26 times than without CPP.
In vitro and in vivo
CCCHHHHTTTHHHHHHHTTTTCC
Evidence 24 Activity

Activity

Cell-penetrating Peptides

Target

Lncap And Hek-293 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
N-myc downstream regulated gene2 (NDRG2) protein
Cytoplasm
TAT-EGFP successfully transduce HEK-293 and LNCaP cells while no fluorescence detected in the cells treated with EGFP without TAT sequence
In vitro
CCCTTCSCCC
Evidence 25 Activity

Activity

Cell-penetrating Peptides

Target

Huh-7, L02 Cells , Hepg2.2.1.5 Cells

Assay & Model

Female HBV transgenic BALB/c mice (6-8 weeks old)
Female HBV transgenic BALB/c mice (6-8 weeks old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
p53 protein
Cytoplasm and nucleus
Significantly higher level of total p53 (2.5-fold in Huh7 or 2.6-fold in L02 cells) with PTD-p53 compared to control cells.
In vitro and in vivo
CCCCCC
Evidence 26 Activity

Activity

Cell-penetrating Peptides

Target

Adult Npcs (Prepared From Adult (8-Week-Old) Mouse Brains)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
wild-type p38 protein
Recombinant PTD-p38WT has constitutive kinase activity and can penetrate NPCs.
In vitro
CCSSCCCCCCCCCCCSSCCCC
Evidence 27 Activity

Activity

Cell-penetrating Peptides

Target

Hek293T Cell Lines, Hippocampal Neurons

Assay & Model

Cdkl5 KO (−/Y) mice
Cdkl5 KO (−/Y) mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
CDKL5 protein and GFP
Cytoplasm
In vitro and in vivo
CCGGGTSCC
Evidence 28 Activity

Activity

Cell-penetrating Peptides

Target

293T Cells

Assay & Model

S. japonicum-infected C57BL/6J mice (6–8 weeks old)
S. japonicum-infected C57BL/6J mice (6–8 weeks old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
TSP2HD antigen (hydrophilic domain of the S. japonicum tetraspanin-2)
In vitro and in vivo
CCTTSSCCCCC
Evidence 29 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231 (Erbb2 Negative) And Sk-Br-3 (Erbb2 Positive) Breast Cancer Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
pertuzumab (an anti-ErbB2 humanized antibody)
Tatibody(TAT + antibody) internalization potency is 3.6 fold higher than pertuzumab
In vitro
CCSSCCCCCCCCCCCSSCCCC
Evidence 30 Activity

Activity

Cell-penetrating Peptides

Target

Ht-22 Cells

Assay & Model

Male gerbils (65~75 g, 6 months)
Male gerbils (65~75 g, 6 months)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
Aldose reductase (AR) protein
Cytoplasm and nucleus
Concentration- and time-dependent internalization
In vitro and in vivo
CCTTSSCCCCC
Evidence 31 Activity

Activity

Cell-penetrating Peptides

Target

Hcn-2 And Ht22 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
Prdx6 protein
In vitro
CTTSHHHHSCC
Evidence 32 Activity

Activity

Cell-penetrating Peptides

Target

Swine Testis Cells (St And Crl-1746)

Assay & Model

Four-week-old specific-pathogen-free Large White pigs
Four-week-old specific-pathogen-free Large White pigs

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
Porcine Mx1 (poMx1)
Cytoplasm
Efficiently penetrate cell membranes within a few hours
In vitro and in vivo
CCTTSSCCCCC
Evidence 33 Activity

Activity

Cell-penetrating Peptides

Target

293 T Cells

Assay & Model

Female BALB/c (H-2d) mice (specific-pathogen-free, SPF) of 6–8 weeks old infected with (H1N1), (H9N2) or (H3N2)
Female BALB/c (H-2d) mice (specific-pathogen-free, SPF) of 6–8 weeks old infected with (H1N1), (H9N2) or (H3N2)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
Nucleoprotein (NP)
In vitro and in vivo
CCGGGTSCC
Evidence 34 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Female BALB/c mice (4-6-week old)
Female BALB/c mice (4-6-week old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
HPV16L2-88 peptide
In vivo
CCGGGTSCC
Evidence 35 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Female BALB/c mice (4-6-week old)
Female BALB/c mice (4-6-week old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
HPV16L2-200 peptide
In vivo
CCTTSSCCCCC
Evidence 36 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells And Lncap Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
Cy3-labelled siRNA and Cy3-labelled Ago2 fusion proteins
Cytoplasm
Cy3 fluorescence of TAT-S19-Ago2 in cells was higher than that of TAT-Ago2
Macropinocytosis
In vitro
CCIIIIIHHHHTSSSTTTTCCTTGGGTCCC
Evidence 37 Activity

Activity

Cell-penetrating Peptides

Target

Human Mesenchymal Stem Cells (Mscs) And MCF-7 Cell

Assay & Model

ICR female mice
ICR female mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
Fluorescent polymer dots (Pdots)
Cytoplasm
~3 times higher than the cell brightness labelled with R8-Pdots and ~10,000 times higher in MCF-7 cells than MSC cells
Endocytosis
In vitro and in vivo
CTTTSCCCCHHHHHTGGGGTC
Evidence 38 Activity

Activity

Cell-penetrating Peptides

Target

Hacat Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Thioredoxin (Trx) form Cyanea capillata (CcTrx1)
Time-dependent (15 min to 2 h) internalization
In vitro
CCCCCCGGGC
Evidence 39 Activity

Activity

Cell-penetrating Peptides

Target

CHO Dg44 Cells, CHO-Grapfurin Cells And Ht1080 Fibrosarcoma Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
In vitro
CCCSSSTTCCCTTTTC
Evidence 40 Activity

Activity

Cell-penetrating Peptides

Target

Human Rbcs

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L
Protein derived
Molecular beacon (miRNA targeting MBs)
Cytoplasm
Specific and strong labeling of the platelet population with CPP conjugate MB.
In vitro
Evidence 41 Activity

Activity

Cell-penetrating Peptides

Target

U2Os Cell

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
Myb(397-415) to C terminal via GC linker
Enhanced permeability
In vitro
CCGGGTSCC
Evidence 42 Activity

Activity

Cell-penetrating Peptides

Target

Llc And 4T1 Cell Line

Assay & Model

Female (six-week-old) C57BL/6 mice
Female (six-week-old) C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
FAM-miRNA-34a
Cytosol
Tat-A86 exhibited the best cell binding and uptake activities of miRNA in LLC cells compared to other ELPs.
IL-4R mediated endocytosis
In vitro and in vivo
CCGGGTSCC
Evidence 43 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
SIP-C1/C2
In vitro
CCCCCCTTCC
Evidence 44 Activity

Activity

Cell-penetrating Peptides

Assay & Model

C57BL/6J mice
C57BL/6J mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
PHDP5 and FITC dye
Cytosol
TAT efficiently delivered PHDP5 to hippocampus.
In vivo
CCCSSSTTCCCTTTTC
Evidence 45 Activity

Activity

Cell-penetrating Peptides

Target

Svz-Nscs, Svz-Egfrwt, Svz-Egfrviii , Nsc-Egfrviii, Np, Npe, And Npe-Ie Cells

Assay & Model

male and female C57BL/6 mice
male and female C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Cx43(266–283)
In vitro and in vivo
CCCSHHHHHHHHHTSSHHHHHHHHGGGTC
Evidence 46 Activity

Activity

Cell-penetrating Peptides

Target

Primary Rat Cortical Neurons , Flash-Frozen Dlpfc Tissues

Assay & Model

Src heterozygous C57BL/6 mice
Src heterozygous C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Src activating PSD-95 inhibitory peptide (SAPIP)
TAT-SAPIP not only penetrates the cell membrane but also decreases Src–PSD-95 association.
In-vitro, in-vivo and ex vivo
CCTTSSCCCCC
Evidence 47 Activity

Activity

Cell-penetrating Peptides

Target

Cg-4 Cells

Assay & Model

C57BL/6J male mice
C57BL/6J male mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Calcitriol and PGD2-G-loaded Lipid nanocapsules (LNC)
In vitro and in vivo
CCBTTBCSSCCCCBTTBCCC
Evidence 48 Activity

Activity

Cell-penetrating Peptides

Target

Primary Neurons And Microglia

Assay & Model

Male C57BL/6JNifdc mice aged 8 weeks
Male C57BL/6JNifdc mice aged 8 weeks

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
SIRT5-CTM and Scr-CTM and FITC dye
Membrane
(FITC)-labeled Tat-SIRT5-CTM was effectively distributed in hippocampal and cortical tissues
In vitro and in vivo
CCCCCSCGGGCCCCCCC
Evidence 49 Activity

Activity

Cell-penetrating Peptides

Target

Jurkat Cells And Mouse Primary T Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
AAV6-green fluorescent protein (AAV6-GFP)
In vitro
CCSCGGGTSCCCCSSHHHHCSCC
Evidence 50 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Acyrthosiphon pisum (pea aphid)
Acyrthosiphon pisum (pea aphid)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
mVenus
The fluorescence emitted by mVenus-TAT was unclear in A. pisum even 24 h after injection suggesting TAT did not deliver mVenus to the aphid tissue.
In vivo
CCCSSSTTCCCTTTTC
Evidence 51 Activity

Activity

Cell-penetrating Peptides

Target

16-Hbe Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L Cationic
Protein derived
nanocomplexes of PHEA-g-bAPAE-PEG-MLB copolymer
Cytoplasm
Polyplexes functionalized with the TAT peptide, the fluorescence is higher when compared with non-functionalized polyplexes, indicating a greater cellular and time-dependent internalization
Endocytosis
In vitro
Evidence 52 Activity

Activity

Cell-penetrating Peptides

Target

Sf9 And Rp-Hzgut-Aw1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
STAR635P fluorophore
Lysosomes
Rapid uptake of CPP through endosomes as Fluorescent vesicles were observed in as little as 20 min.
Endocytosis
In vitro and ex vivo
CBTTTBCCC
Evidence 53 Activity

Activity

Cell-penetrating Peptides

Target

Sk-Hep1, SH-SY5Y

Assay & Model

Male C57BL6 mice (8 weeks old, 19–22 g)
Male C57BL6 mice (8 weeks old, 19–22 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Human metallothionein 1A (hMT1A)
Cytosol
TAT-hMT1A construct without the MTS was found only in the cytosol and its levels decreased
In vitro and in vivo
CCSCTTGGGHHHHHHHTTSCCC
Evidence 54 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 Cell Line

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
S100A1-derived peptide
Cytosol and Nucleus
Both the TAT-fused peptides, 1 and 2, were able to penetrate the cell membrane and reached the area of cytosol and nucleus compartments.
In vitro
CCTTSSCCCCC
Evidence 55 Activity

Activity

Cell-penetrating Peptides

Target

RAW264.7 Cells

Assay & Model

Six to eight-week-old female BALB/c mice (weighing 25−30 g)
Six to eight-week-old female BALB/c mice (weighing 25−30 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
FITC-labeled KR-12
Cytoplasm
61.5 ± 4.8% of the FITC-labeled TAT-KR-12-treated RAW264.7 cells exhibited fluorescence, which is much higher than the result of FITC-KR-12 treated cells (22.4 ± 3.5%).
In vitro and in vivo
CCCCCCC
Evidence 56 Activity

Activity

Cell-penetrating Peptides

Target

T24,H460, Nhlf And MCF-7 Cells

Assay & Model

Male athymic nude mice (16–18 g)
Male athymic nude mice (16–18 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Fluorescein isothiocyanate (FITC)-labeled Interleukin-24 (IL-24) at C-terminal of TAT
Endoplasmic Reticulum
Both TAT-IL-24-KDEL and TAT-IL-24 transfected T24 cells with the efficiency of 97.3% and 96.5%, whereas nearly no green fluorescence was observed in IL-24-treated cells.
In vitro and in vivo
CCCCTTTTGGGCCCCCBTTBCC
Evidence 57 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Male Sprague-Dawley (SD) rats (Grade SPF, 250–300 g)
Male Sprague-Dawley (SD) rats (Grade SPF, 250–300 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
eGFP and brain-derived neurotrophic factor (BDNF)
After 4h, a robust eGFP signal was observed in the hippocampus, hypothalamus, and amygdala of the rat's brain. and 70 % of brain areas are found eGFP-positive by co-staining with Hoechst.
In vivo
CCCCCCCC
Evidence 58 Activity

Activity

Cell-penetrating Peptides

Target

hCMEC Cells And U251/hCMEC Co-Culture Bbb Model

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
FITC-labeled SiO2@Fe3O4 nanoparticles (NPs)
Cytoplasm and nucleus
Conjugation with peptide Tat could enhance by 1.2–2.2 times cellular uptake on varied explosion time (0–2 h) relative to Fe3O4@SiO2-Amino NPs,
Magnet aid endocytosis process
In vitro
CCC
Evidence 59 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, MCF-7, Hep G2 And A549 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Doxorubicin (DOX) loaded quantum dots (QDs)
Nucleus
In all the four different cell lines tested, namely HeLa (cervix), MCF-7 (breast), Hep G2 (liver), and A549 (lung), 1% DMSO showed a drastic increase for the nucleus targeting of QDs-Tat (increase from ∼5% to ∼55%)
Endocytosis
In vitro
CCTTSSCCCCCCCTTHHHHTTSSCCC
Evidence 60 Activity

Activity

Cell-penetrating Peptides

Target

Hepg2 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
FITC-labeled Carboxypeptidase G2 (CPG2)
Transduction efficiency of denatured TAT-CPG2 was higher than the native protein. No transduction has been observed in cells treated with the control CPG2 protein
In vitro
CCCCSGGGSSCC
Evidence 61 Activity

Activity

Cell-penetrating Peptides

Target

Mrsa Infected Hacat Keratinocytes

Assay & Model

BALB/c female mice aged 6 weeks
BALB/c female mice aged 6 weeks

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
Staphylococcus phage JD007 (JDlys) at C terminus
Tat-JDlys exhibited a greater ability to kill intracellular MRSA strains than JDlys, indicating that Tat could deliver JDlys into keratinocytes, while, neither Ant-JDlys nor Tp10-JDlys could eliminate intracellular MRSA.
In vitro and in vivo
CCCCCBCSSSBGGGGGSCCC
Evidence 62 Activity

Activity

Cell-penetrating Peptides

Target

Jurkat T Cells, HeLa Cells

Assay & Model

10-week-old female C57BL/6 mice
10-week-old female C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
Leucine-rich repeat domain (LRR) of NLRX1
Cytosol
In vitro and in vivo
CCGGGGGGGGCCCGGGGGGGCSCC
Evidence 63 Activity

Activity

Cell-penetrating Peptides

Target

B16F10 Melanocytes

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L
Protein derived
FITC-labeled tyrosine ammonia-lyase from Rhodobacter sphaeroides (RsTAL) at C terminus
FITC- labeled TAT-RsTAL was delivered into the melanocytes successfully and at 180 min showed the highest fluorescence intensity.
In vitro
Evidence 64 Activity

Activity

Cell-penetrating Peptides

Target

Hepg2 And Qsg-7701 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Manganese superoxide dismutase (MnSOD)
TAT-MnSOD wt led to the increase in the intracellular enzymatic activity of MnSOD, while the Inactive TAT-MnSOD mutant failed in induction of the intracellular enzymatic activity of MnSOD.
In vitro
CCGGGTSCC
Evidence 65 Activity

Activity

Cell-penetrating Peptides

Target

Ht-1080 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
Near-infrared fluorescent DY676 labelled cargos (BSA, monoclonal Ab)
Golgi/Late Endosomal Localization
HIV-TAT(47–57) was unable to transport BSA or Trastuzumab
In vitro
CCCCCCCCC
Evidence 66 Activity

Activity

Cell-penetrating Peptides

Target

Mouse Escs, Thymic Epithelial Cells (Tecs)

Assay & Model

Congenic and allogeneic HSCT recipient mice
Congenic and allogeneic HSCT recipient mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Recombinant FOXN1 protein (rFOXN1)
Cytoplasm and nucleus
In vitro and in vivo
CCCCCCCSCCCCSCSSCCC
Evidence 67 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, Nih 3T3 And A549 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Cyclic L Cationic
Protein derived
Fluorescein isothiocyanate (FITC), rhodamine B (Rho), or naphthofluorescein (NF)-labelled
Cytoplasm
Tat and R9 were ~2-fold less efficiently than cFΦR4
In vitro
Evidence 68 Activity

Activity

Cell-penetrating Peptides

Target

Ma-104 And Caco-2

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Fluorescein and rhodamine B dye
Cytoplasm
Endocytosis
In vitro
CCCCCCCCCCCCC
Evidence 69 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, THP-1 Cells ,A431, Hepg2, Sk-N-Sh, THP-1

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Enhanced green fluorescent protein (eGFP)
In vitro
CCCCCCCCC
Evidence 70 Activity

Activity

Cell-penetrating Peptides

Target

Neuro2A

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L
Protein derived
Peptide-based polyplexes (PAA)
Improved transfection efficiency
In vitro
Evidence 71 Activity

Activity

Cell-penetrating Peptides

Target

Porcine Fetal Fibroblasts

Assay & Model

Pig
Pig

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
Alexa Fluor488 labelled Cre recombinase protein
Endocytic Vesicles
Endocytosis
In vitro and in vivo
CCSSCCSCTTCC
Evidence 72 Activity

Activity

Cell-penetrating Peptides

Target

Cultured Mucosal Explants (Enterocytes)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Cytosol
Endocytosis
In vitro
CCCCSBTTBCCCSCC
Evidence 73 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Normal BL6 mice, dystrophin-null mdx4cv mice and ∆R4 transgenic mice
Normal BL6 mice, dystrophin-null mdx4cv mice and ∆R4 transgenic mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L Cationic
Protein derived
Palmitoylated (Pal) R16/17-GFP protein
In vivo
Evidence 74 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2 Cells Bacteroidetes (Bacteroides Vulgatus And Bacteroides Thetaiotaomicron), Firmicutes (Lactobacillus Gasseri, Latilactobacillus Sakei, And Clostridium Bolteae), Actinomicetya (Bifidobacterium Longum, And Bifidobacterium Adolescentis) , Proteobacteria (Escherichia Coli Nissle 1917 And Escherichia Coli K12) And Saccharomyces Boulardii

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
FITC-dextran
In vitro
CCCCCCTTCC
Evidence 75 Activity

Activity

Cell-penetrating Peptides

Target

Df-1, Vero And RAW264.7 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
FITC dye, SYTO 64 fluorescent dye, plasmids ,SUMO-Rep or SUMO-Cap protein and CAV VP3 gene
Cytoplasm and Nuclear Areas
80.07±1.16 internalization percentages of the cells treated with 5 μM TAT
Clathrin- and Caveolae-dependent endocytosis and macropinocytosis
In vitro
CCCCCCCCC
Evidence 76 Activity

Activity

Cell-penetrating Peptides

Target

HEK293T cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L Cationic
Protein derived
Cre protein and Rhodamine dye
Cytoplasm
Tat brush polymer promoted significant levels of Cre delivery
Endocytosis
In vitro
Evidence 77 Activity

Activity

Cell-penetrating Peptides

Target

S. pneumoniae, multidrug-resistant E. coli, and MRSA

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Liposomes loaded with vancomycin, methicillin, and ampicillin
In vitro
CHHHHGGGGHHHHTTCCC
Evidence 78 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Outbred female Swiss (CD-1) mice (7–8 weeks old)
Outbred female Swiss (CD-1) mice (7–8 weeks old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
lipopeptide-based vaccine (LCP-1)
In vivo
CCCCCCCCSSCCC
Evidence 79 Activity

Activity

50% Hemolysis
Toxicity
>300 µM
Hemolytic Cytotoxic
50% Hemolysis | >300 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Comparative analysis of internalisation, haemolytic, cytotoxic and antibacterial effect of membrane-active cationic peptides: aspects of experimental setup. | Amino Acids | 2017
Evidence 80 Activity

Activity

IC50
Toxicity
>300 µM
Cytotoxic
IC50 | >300 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Comparative analysis of internalisation, haemolytic, cytotoxic and antibacterial effect of membrane-active cationic peptides: aspects of experimental setup. | Amino Acids | 2017
Evidence 81 Activity

Activity

5% Hemolysis
Toxicity
>62.5 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | >62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
DNA/Lysozyme-binding affinity study of novel peptides from TAT (47-57) and BRCA1 (782-786) in vitro by spectroscopic analysis. | Spectrochim Acta A Mol Biomol Spectrosc | 2019
Evidence 82 Activity

Activity

Tumor-homing Peptides

Target

Homing

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumour lineage-homing cell-penetrating peptides as anticancer molecular delivery systems
2012
Eisaku Kondo et al. Nat Commun. 2012 Jul 17:3:951.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
mRNA display library
Additional Detail Fields 1 fields
CCTTSSCCCCC CCCHHHHTTTHHHHHHHTTTTCC CCCTTCSCCC CCCCCC CCSSCCCCCCCCCCCSSCCCC CCGGGTSCC CTTSHHHHSCC CCIIIIIHHHHTSSSTTTTCCTTGGGTCCC CTTTSCCCCHHHHHTGGGGTC CCCCCCGGGC CCCSSSTTCCCTTTTC CCCCCCTTCC CCCSHHHHHHHHHTSSHHHHHHHHGGGTC CCBTTBCSSCCCCBTTBCCC CCCCCSCGGGCCCCCCC CCSCGGGTSCCCCSSHHHHCSCC CBTTTBCCC CCSCTTGGGHHHHHHHTTSCCC CCCCCCC CCCCTTTTGGGCCCCCBTTBCC CCCCCCCC CCC CCTTSSCCCCCCCTTHHHHTTSSCCC CCCCSGGGSSCC CCCCCBCSSSBGGGGGSCCC CCGGGGGGGGCCCGGGGGGGCSCC CCCCCCCCC CCCCCCCSCCCCSCSSCCC CCCCCCCCCCCCC CCSSCCSCTTCC CCCCSBTTBCCCSCC CHHHHGGGGHHHHTTCCC CCCCCCCCSSCCC