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Peptide record

TPDB06404

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB06404
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
KKLFKKILKFL
Physicochemical Analysis
C72H124N16O12
ARNDCEQGHMPSTWYV
K
1405.88
11.12
5
0
6
+5
0.70
0.182
141.82
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
3
L
5
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 5 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C72H124N16O12
1405.88
11.12
+5
0.70
0.182
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against Gram- E. coli (MIC 8 ug/ml), P. aeruginosa (MIC 16 ug/ml), Gram+ S. aeurus (MIC 62.3 ug/ml), fungi C. albicans (MIC 2
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

active against Gram- E. coli (MIC 8 ug/ml), P. aeruginosa (MIC 16 ug/ml), Gram+ S. aeurus (MIC 62.3 ug/ml), fungi C. albicans (MIC 25 ug/ml), and F. solani (MIC 5
Evidence 3 Activity

Activity

MIC
Antibacterial
62.3 µg/mL

Target

S. aeurus

Source & Reference

dbAMP

Other

active against Gram- E. coli (MIC 8 ug/ml), P. aeruginosa (MIC 16 ug/ml), Gram+ S. aeurus (MIC 62.3 ug/ml), fungi C. albicans (MIC 25 ug/ml), and F. solani (MIC 50 ug/ml). Also active against P. s
Evidence 4 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Candida albicans

Source & Reference

dbAMP

Other

coli (MIC 8 ug/ml), P. aeruginosa (MIC 16 ug/ml), Gram+ S. aeurus (MIC 62.3 ug/ml), fungi C. albicans (MIC 25 ug/ml), and F. solani (MIC 50 ug/ml). Also active against P. syringae pv. syringae (MIC 2.5-5 uM
Evidence 5 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

F. solani

Source & Reference

dbAMP

Other

a (MIC 16 ug/ml), Gram+ S. aeurus (MIC 62.3 ug/ml), fungi C. albicans (MIC 25 ug/ml), and F. solani (MIC 50 ug/ml). Also active against P. syringae pv. syringae (MIC 2.5-5 uM), X. axonopodis pv. vesicator
Evidence 6 Activity

Activity

MIC
Antibacterial
2.5-5 µM

Target

v. syringae

Source & Reference

dbAMP

Other

. albicans (MIC 25 ug/ml), and F. solani (MIC 50 ug/ml). Also active against P. syringae pv. syringae (MIC 2.5-5 uM), X. axonopodis pv. vesicatoria (MIC 2.5-5.0 uM), and E. amylovora (MIC 2.5-5.0 uM)
Evidence 7 Activity

Activity

MIC
Antibacterial
2.5-5.0 µM

Target

v. vesicatoria

Source & Reference

dbAMP

Other

IC 50 ug/ml). Also active against P. syringae pv. syringae (MIC 2.5-5 uM), X. axonopodis pv. vesicatoria (MIC 2.5-5.0 uM), and E. amylovora (MIC 2.5-5.0 uM)
Evidence 8 Activity

Activity

MIC
Antibacterial
2.5-5.0 µM

Target

E. amylovora

Source & Reference

dbAMP

Other

syringae pv. syringae (MIC 2.5-5 uM), X. axonopodis pv. vesicatoria (MIC 2.5-5.0 uM), and E. amylovora (MIC 2.5-5.0 uM)
Evidence 9 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against Gram- E. coli (MIC 8 ug/ml), P. aeruginosa (MIC 16 ug/ml), Gram+ S. aeurus (MIC 62.3 ug/ml), fungi C. albicans (MIC 2
Evidence 10 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against Gram- E. coli (MIC 8 ug/ml), P. aeruginosa (MIC 16 ug/ml), Gram+ S. aeurus (MIC 62.3 ug/ml), fungi C. albicans (MIC 25 ug/ml), and F. solani (MIC 5
Evidence 11 Activity

Activity

MIC
Antifungal
62.3 µg/mL

Target

S. aeurus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against Gram- E. coli (MIC 8 ug/ml), P. aeruginosa (MIC 16 ug/ml), Gram+ S. aeurus (MIC 62.3 ug/ml), fungi C. albicans (MIC 25 ug/ml), and F. solani (MIC 50 ug/ml). Also active against P. s
Evidence 12 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

coli (MIC 8 ug/ml), P. aeruginosa (MIC 16 ug/ml), Gram+ S. aeurus (MIC 62.3 ug/ml), fungi C. albicans (MIC 25 ug/ml), and F. solani (MIC 50 ug/ml). Also active against P. syringae pv. syringae (MIC 2.5-5 uM
Evidence 13 Activity

Activity

MIC
Antifungal
50 µg/mL

Target

F. solani

Source & Reference

dbAMP CAFPdb Antifungipept

Other

a (MIC 16 ug/ml), Gram+ S. aeurus (MIC 62.3 ug/ml), fungi C. albicans (MIC 25 ug/ml), and F. solani (MIC 50 ug/ml). Also active against P. syringae pv. syringae (MIC 2.5-5 uM), X. axonopodis pv. vesicator
Evidence 14 Activity

Activity

MIC
Antifungal
2.5-5 µM

Target

v. syringae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

. albicans (MIC 25 ug/ml), and F. solani (MIC 50 ug/ml). Also active against P. syringae pv. syringae (MIC 2.5-5 uM), X. axonopodis pv. vesicatoria (MIC 2.5-5.0 uM), and E. amylovora (MIC 2.5-5.0 uM)
Evidence 15 Activity

Activity

MIC
Antifungal
2.5-5.0 µM

Target

v. vesicatoria

Source & Reference

dbAMP CAFPdb Antifungipept

Other

IC 50 ug/ml). Also active against P. syringae pv. syringae (MIC 2.5-5 uM), X. axonopodis pv. vesicatoria (MIC 2.5-5.0 uM), and E. amylovora (MIC 2.5-5.0 uM)
Evidence 16 Activity

Activity

MIC
Antifungal
2.5-5.0 µM

Target

E. amylovora

Source & Reference

dbAMP CAFPdb Antifungipept

Other

syringae pv. syringae (MIC 2.5-5 uM), X. axonopodis pv. vesicatoria (MIC 2.5-5.0 uM), and E. amylovora (MIC 2.5-5.0 uM)
Evidence 17 Activity

Activity

40% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
40% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A library of linear undecapeptides with bactericidal activity against phytopathogenic bacteria. | Peptides | 2007
Evidence 18 Activity

Activity

85% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
85% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A library of linear undecapeptides with bactericidal activity against phytopathogenic bacteria. | Peptides | 2007
Evidence 19 Activity

Activity

50% Hemolysis
Toxicity
400 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 400 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel short antibacterial and antifungal peptides with low cytotoxicity: Efficacy and action mechanisms. | Biochem Biophys Res Commun | 2010
Evidence 20 Activity

Activity

50% Hemolysis
Toxicity
203 µM
Hemolytic Cytotoxic
50% Hemolysis | 203 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Inhibition of plant-pathogenic bacteria by short synthetic cecropin A-melittin hybrid peptides. | Appl Environ Microbiol | 2006
Evidence 21 Activity

Activity

34±2.1% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
34±2.1% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 22 Activity

Activity

IC50
Toxicity
13.5±0.7 µM
Cytotoxic
IC50 | 13.5±0.7 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Identification of BP16 as a non-toxic cell-penetrating peptide with highly efficient drug delivery properties. | Org Biomol Chem | 2014
Evidence 23 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis