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Peptide record

TPDB06402

Antibacterial Antifungal Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB06402
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
VAEARQGSFSY
Physicochemical Analysis
C53H79N15O18
NDCHILKMPTW
AS
1214.30
6.90
1
1
5
-0
1.34
-0.382
44.55
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1490
122.70
4
Residue Composition
number
2
A
1
R
0
N
0
D
0
C
1
E
1
Q
1
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
2
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
11
C53H79N15O18
1214.30
6.90
-0
1.34
-0.382
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
15.1 ug/mL

Target

S. Typhimurinum ATCC 14028

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- P. aeruginosa ATCC 27853, A. faecalis ATCC 8750, E. coli D31, S. Typhimurinum ATCC 14028 (MIC 15.1 ug/mL), E. coli SBS 363, S. marcescens ATCC 4112 , E. cloacae beta-12, S. Arizonae ATCC 13314 (M
Evidence 2 Activity

Activity

MIC
Antibacterial
30.33 ug/mL

Target

S. Arizonae ATCC 13314

Source & Reference

dbAMP

Other

CC 14028 (MIC 15.1 ug/mL), E. coli SBS 363, S. marcescens ATCC 4112 , E. cloacae beta-12, S. Arizonae ATCC 13314 (MIC 30.33 ug/mL), Gram+ M. luteus A270, S. aureus ATCC 29213 (MIC 7.6 ug/mL), B. megaterium ATCC 10778 (MI
Evidence 3 Activity

Activity

MIC
Antibacterial
7.6 ug/mL

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP

Other

112 , E. cloacae beta-12, S. Arizonae ATCC 13314 (MIC 30.33 ug/mL), Gram+ M. luteus A270, S. aureus ATCC 29213 (MIC 7.6 ug/mL), B. megaterium ATCC 10778 (MIC 15.2 ug/mL), B. subtilis ATCC 6633 (MIC 30.33 ug/mL), yeas
Evidence 4 Activity

Activity

MIC
Antibacterial
15.2 ug/mL

Target

B. megaterium ATCC 10778

Source & Reference

dbAMP

Other

ATCC 13314 (MIC 30.33 ug/mL), Gram+ M. luteus A270, S. aureus ATCC 29213 (MIC 7.6 ug/mL), B. megaterium ATCC 10778 (MIC 15.2 ug/mL), B. subtilis ATCC 6633 (MIC 30.33 ug/mL), yeasts C. albicans MDM8, C. tropicalis IOC 4560
Evidence 5 Activity

Activity

MIC
Antibacterial
30.33 ug/mL

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP

Other

us A270, S. aureus ATCC 29213 (MIC 7.6 ug/mL), B. megaterium ATCC 10778 (MIC 15.2 ug/mL), B. subtilis ATCC 6633 (MIC 30.33 ug/mL), yeasts C. albicans MDM8, C. tropicalis IOC 4560, S. cerevisiae PM340, fungii A. niger, a
Evidence 6 Activity

Activity

MIC
Antibacterial
30.3 ug/mL

Target

B. bassiana

Source & Reference

dbAMP

Other

easts C. albicans MDM8, C. tropicalis IOC 4560, S. cerevisiae PM340, fungii A. niger, and B. bassiana (MIC 30.3 ug/mL).MBC values are similar to MIC. The peptide appears to inhibit protein synthesis. 7/2021
Evidence 7 Activity

Activity

MIC
Antifungal
15.1 ug/mL

Target

S. Typhimurinum ATCC 14028

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- P. aeruginosa ATCC 27853, A. faecalis ATCC 8750, E. coli D31, S. Typhimurinum ATCC 14028 (MIC 15.1 ug/mL), E. coli SBS 363, S. marcescens ATCC 4112 , E. cloacae beta-12, S. Arizonae ATCC 13314 (M
Evidence 8 Activity

Activity

MIC
Antifungal
30.33 ug/mL

Target

S. Arizonae ATCC 13314

Source & Reference

dbAMP CAFPdb Antifungipept

Other

CC 14028 (MIC 15.1 ug/mL), E. coli SBS 363, S. marcescens ATCC 4112 , E. cloacae beta-12, S. Arizonae ATCC 13314 (MIC 30.33 ug/mL), Gram+ M. luteus A270, S. aureus ATCC 29213 (MIC 7.6 ug/mL), B. megaterium ATCC 10778 (MI
Evidence 9 Activity

Activity

MIC
Antifungal
7.6 ug/mL

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP CAFPdb Antifungipept

Other

112 , E. cloacae beta-12, S. Arizonae ATCC 13314 (MIC 30.33 ug/mL), Gram+ M. luteus A270, S. aureus ATCC 29213 (MIC 7.6 ug/mL), B. megaterium ATCC 10778 (MIC 15.2 ug/mL), B. subtilis ATCC 6633 (MIC 30.33 ug/mL), yeas
Evidence 10 Activity

Activity

MIC
Antifungal
15.2 ug/mL

Target

B. megaterium ATCC 10778

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ATCC 13314 (MIC 30.33 ug/mL), Gram+ M. luteus A270, S. aureus ATCC 29213 (MIC 7.6 ug/mL), B. megaterium ATCC 10778 (MIC 15.2 ug/mL), B. subtilis ATCC 6633 (MIC 30.33 ug/mL), yeasts C. albicans MDM8, C. tropicalis IOC 4560
Evidence 11 Activity

Activity

MIC
Antifungal
30.33 ug/mL

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP CAFPdb Antifungipept

Other

us A270, S. aureus ATCC 29213 (MIC 7.6 ug/mL), B. megaterium ATCC 10778 (MIC 15.2 ug/mL), B. subtilis ATCC 6633 (MIC 30.33 ug/mL), yeasts C. albicans MDM8, C. tropicalis IOC 4560, S. cerevisiae PM340, fungii A. niger, a
Evidence 12 Activity

Activity

MIC
Antifungal
30.3 ug/mL

Target

B. bassiana

Source & Reference

dbAMP CAFPdb Antifungipept

Other

easts C. albicans MDM8, C. tropicalis IOC 4560, S. cerevisiae PM340, fungii A. niger, and B. bassiana (MIC 30.3 ug/mL).MBC values are similar to MIC. The peptide appears to inhibit protein synthesis. 7/2021
Evidence 13 Activity

Activity

0% Hemolysis
Toxicity
4-250 µM
Hemolytic Cytotoxic
0% Hemolysis | 4-250 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity and mechanism of action of a novel peptide present in the ecdysis process of centipede Scolopendra subspinipes subspinipes. | Sci Rep | 2019
Evidence 14 Activity

Activity

25.14% Hemolysis
Toxicity
500 µM
Hemolytic Cytotoxic
25.14% Hemolysis | 500 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity and mechanism of action of a novel peptide present in the ecdysis process of centipede Scolopendra subspinipes subspinipes. | Sci Rep | 2019
Evidence 15 Activity

Activity

0% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 32 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Evaluation of Short-Chain Antimicrobial Peptides With Combined Antimicrobial and Anti inflammatory Bioactivities for the Treatment of Zoonotic Skin Pathogens From Canines. | Front Microbiol | 2021
Evidence 16 Activity

Activity

<5% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 256 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Evaluation of Short-Chain Antimicrobial Peptides With Combined Antimicrobial and Anti inflammatory Bioactivities for the Treatment of Zoonotic Skin Pathogens From Canines. | Front Microbiol | 2021
Evidence 17 Activity

Activity

0% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 32 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Evaluation of Short-Chain Antimicrobial Peptides With Combined Antimicrobial and Anti inflammatory Bioactivities for the Treatment of Zoonotic Skin Pathogens From Canines. | Front Microbiol | 2021
Evidence 18 Activity

Activity

<5% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 256 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Evaluation of Short-Chain Antimicrobial Peptides With Combined Antimicrobial and Anti inflammatory Bioactivities for the Treatment of Zoonotic Skin Pathogens From Canines. | Front Microbiol | 2021