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Peptide record

TPDB06400

Antibacterial Antifungal Toxicity standard

11 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB06400

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 11-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.

Sequence

KKVVFKVKFKK

FASTA

>TPDB06400|Antibacterial;Antifungal;Toxicity|length=11
KKVVFKVKFKK

Formula C69H119N17O12

Absent Amino Acids ARNDCEQGHILMPSTWY

Common Amino Acids K

Mass 1378.81

PI 11.21

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +6

Boman Index 3.89

Hydrophobicity -0.473

Aliphatic Index 79.09

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 6 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 3

Length

Formula

C69H119N17O12

Mass

1378.81

11.21

Net Charge

Boman Index

3.89

Hydrophobicity

-0.473

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram- E. coli ATCC 25922 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 2 uM), Gram+ S. aure

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram- E. coli ATCC 25922 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 2 uM), Gram+ S. aureus ATCC 25923 (MIC 1 uM), S. epidermi

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Klebsiella pneumoniae ATCC 700603

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram- E. coli ATCC 25922 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 2 uM), Gram+ S. aureus ATCC 25923 (MIC 1 uM), S. epidermidis ATCC 12228 (MIC 4 uM), S. pneumoni

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source NA

Other

Evidence Text

C 4 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 2 uM), Gram+ S. aureus ATCC 25923 (MIC 1 uM), S. epidermidis ATCC 12228 (MIC 4 uM), S. pneumoniae ATCC 49619 (MIC 8 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Staphylococcus epidermidis ATCC 12228

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 2 uM), Gram+ S. aureus ATCC 25923 (MIC 1 uM), S. epidermidis ATCC 12228 (MIC 4 uM), S. pneumoniae ATCC 49619 (MIC 8 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism S. pneumoniae ATCC 49619

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 2 uM), Gram+ S. aureus ATCC 25923 (MIC 1 uM), S. epidermidis ATCC 12228 (MIC 4 uM), S. pneumoniae ATCC 49619 (MIC 8 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source CAFPdb Antifungipept

Other

Evidence Text

active against Gram- E. coli ATCC 25922 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 2 uM), Gram+ S. aure

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source CAFPdb Antifungipept

Other

Evidence Text

active against Gram- E. coli ATCC 25922 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 2 uM), Gram+ S. aureus ATCC 25923 (MIC 1 uM), S. epidermi

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism Klebsiella pneumoniae ATCC 700603

Source & Reference

Database Source CAFPdb Antifungipept

Other

Evidence Text

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source CAFPdb Antifungipept

Other

Evidence Text

C 4 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 2 uM), Gram+ S. aureus ATCC 25923 (MIC 1 uM), S. epidermidis ATCC 12228 (MIC 4 uM), S. pneumoniae ATCC 49619 (MIC 8 uM).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism Staphylococcus epidermidis ATCC 12228

Source & Reference

Database Source CAFPdb Antifungipept

Other

Evidence Text

(MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 2 uM), Gram+ S. aureus ATCC 25923 (MIC 1 uM), S. epidermidis ATCC 12228 (MIC 4 uM), S. pneumoniae ATCC 49619 (MIC 8 uM).

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism S. pneumoniae ATCC 49619

Source & Reference

Database Source CAFPdb Antifungipept

Other

Evidence Text

(MIC 2 uM), Gram+ S. aureus ATCC 25923 (MIC 1 uM), S. epidermidis ATCC 12228 (MIC 4 uM), S. pneumoniae ATCC 49619 (MIC 8 uM).

Evidence 13 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

- | NA | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

The comparison of characteristics between membrane-active antifungal peptide and its pseudopeptides. | Bioorg Med Chem | 1999