TPDB06382

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.3 µg/mL

Target

Target Organism B. subtilis ATCC 6633

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against Gram+ B. subtilis ATCC 6633 (MIC 6.3 ug/ml), S. aureus ATCC 6538p (MIC 6.3 ug/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.3 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 6538p

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against Gram+ B. subtilis ATCC 6633 (MIC 6.3 ug/ml), S. aureus ATCC 6538p (MIC 6.3 ug/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. c

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.3 µg/mL

Target

Target Organism S.epidermis ATCC 12228

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

gainst Gram+ B. subtilis ATCC 6633 (MIC 6.3 ug/ml), S. aureus ATCC 6538p (MIC 6.3 ug/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dyse

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.3 µg/mL

Target

Target Organism M. luteus ATCC 10240

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

6.3 ug/ml), S. aureus ATCC 6538p (MIC 6.3 ug/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. p

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.3 µg/mL

Target

Target Organism S. dysentariae ATCC 9752

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism S. typhimorium ATCC 14028

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and P. aeruginosa ATCC 27853 (MIC 25 ug/ml).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.3 µg/mL

Target

Target Organism Klebsiella pneumoniae ATCC 10031

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and P. aeruginosa ATCC 27853 (MIC 25 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

, S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and P. aeruginosa ATCC 27853 (MIC 25 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.3 µg/mL

Target

Target Organism B. subtilis ATCC 6633

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against Gram+ B. subtilis ATCC 6633 (MIC 6.3 ug/ml), S. aureus ATCC 6538p (MIC 6.3 ug/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.3 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 6538p

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

active against Gram+ B. subtilis ATCC 6633 (MIC 6.3 ug/ml), S. aureus ATCC 6538p (MIC 6.3 ug/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. c

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.3 µg/mL

Target

Target Organism S.epidermis ATCC 12228

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

gainst Gram+ B. subtilis ATCC 6633 (MIC 6.3 ug/ml), S. aureus ATCC 6538p (MIC 6.3 ug/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dyse

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.3 µg/mL

Target

Target Organism M. luteus ATCC 10240

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

6.3 ug/ml), S. aureus ATCC 6538p (MIC 6.3 ug/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S.

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.5 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. p

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.3 µg/mL

Target

Target Organism S. dysentariae ATCC 9752

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism S. typhimorium ATCC 14028

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and P. aeruginosa ATCC 27853 (MIC 25 ug/ml).

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.3 µg/mL

Target

Target Organism Klebsiella pneumoniae ATCC 10031

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and P. aeruginosa ATCC 27853 (MIC 25 ug/ml).

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

, S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and P. aeruginosa ATCC 27853 (MIC 25 ug/ml).

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6.3 µg/mL

Target

Target Organism B. subtilis ATCC 6633

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

active against Gram+ B. subtilis ATCC 6633 (MIC 6.3 ug/ml), S. aureus ATCC 6538p (MIC 6.3 ug/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6.3 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 6538p

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against Gram+ B. subtilis ATCC 6633 (MIC 6.3 ug/ml), S. aureus ATCC 6538p (MIC 6.3 ug/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. c

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6.3 µg/mL

Target

Target Organism S.epidermis ATCC 12228

Source & Reference

Database Source DRAMP

Other

Evidence Text

gainst Gram+ B. subtilis ATCC 6633 (MIC 6.3 ug/ml), S. aureus ATCC 6538p (MIC 6.3 ug/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dyse

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6.3 µg/mL

Target

Target Organism M. luteus ATCC 10240

Source & Reference

Database Source DRAMP

Other

Evidence Text

6.3 ug/ml), S. aureus ATCC 6538p (MIC 6.3 ug/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S.

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 12.5 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source DRAMP

Other

Evidence Text

/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. p

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6.3 µg/mL

Target

Target Organism S. dysentariae ATCC 9752

Source & Reference

Database Source DRAMP

Other

Evidence Text

ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µg/mL

Target

Target Organism S. typhimorium ATCC 14028

Source & Reference

Database Source DRAMP

Other

Evidence Text

ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and P. aeruginosa ATCC 27853 (MIC 25 ug/ml).

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6.3 µg/mL

Target

Target Organism Klebsiella pneumoniae ATCC 10031

Source & Reference

Database Source DRAMP

Other

Evidence Text

/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and P. aeruginosa ATCC 27853 (MIC 25 ug/ml).

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µg/mL

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source DRAMP

Other

Evidence Text

, S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and P. aeruginosa ATCC 27853 (MIC 25 ug/ml).

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.3 µg/mL

Target

Target Organism B. subtilis ATCC 6633

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

active against Gram+ B. subtilis ATCC 6633 (MIC 6.3 ug/ml), S. aureus ATCC 6538p (MIC 6.3 ug/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.3 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 6538p

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against Gram+ B. subtilis ATCC 6633 (MIC 6.3 ug/ml), S. aureus ATCC 6538p (MIC 6.3 ug/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. c

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.3 µg/mL

Target

Target Organism S.epidermis ATCC 12228

Source & Reference

Database Source DRAMP

Other

Evidence Text

gainst Gram+ B. subtilis ATCC 6633 (MIC 6.3 ug/ml), S. aureus ATCC 6538p (MIC 6.3 ug/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dyse

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.3 µg/mL

Target

Target Organism M. luteus ATCC 10240

Source & Reference

Database Source DRAMP

Other

Evidence Text

6.3 ug/ml), S. aureus ATCC 6538p (MIC 6.3 ug/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S.

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 12.5 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source DRAMP

Other

Evidence Text

/ml), S.epidermis ATCC 12228 (MIC 6.3 ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. p

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.3 µg/mL

Target

Target Organism S. dysentariae ATCC 9752

Source & Reference

Database Source DRAMP

Other

Evidence Text

ug/ml), M. luteus ATCC 10240 (MIC 6.3 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and

Evidence 34 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 25 µg/mL

Target

Target Organism S. typhimorium ATCC 14028

Source & Reference

Database Source DRAMP

Other

Evidence Text

ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and P. aeruginosa ATCC 27853 (MIC 25 ug/ml).

Evidence 35 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.3 µg/mL

Target

Target Organism Klebsiella pneumoniae ATCC 10031

Source & Reference

Database Source DRAMP

Other

Evidence Text

/ml), S. dysentariae ATCC 9752 (MIC 6.3 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and P. aeruginosa ATCC 27853 (MIC 25 ug/ml).

Evidence 36 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 25 µg/mL

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source DRAMP

Other

Evidence Text

, S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and P. aeruginosa ATCC 27853 (MIC 25 ug/ml).

Evidence 37 Activity

Activity

Activity Endpoint 7% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

7% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

De novo generation of antimicrobial LK peptides with a single tryptophan at the critical amphipathic interface. | J Pept Sci | 2009

Evidence 38 Activity

Activity

Activity Endpoint 6% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

6% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

De novo generation of antimicrobial LK peptides with a single tryptophan at the critical amphipathic interface. | J Pept Sci | 2009

Evidence 39 Activity

Activity

Activity Endpoint 5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 32-6.3 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

5% Hemolysis | 32-6.3 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Evidence 40 Hemolysis

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.