Back to search

Peptide record

TPDB06378

Antibacterial Anticancer Hemolysis Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB06378
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia PD_Hemolysis
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RRLFRRILRYL
Physicochemical Analysis
C72H124N26O13
ANDCEQGHKMPSTWV
R
1561.94
12.58
5
0
6
+5
-0.01
-0.464
141.82
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
95.39
1
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
3
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
11
C72H124N26O13
1561.94
12.58
+5
-0.01
-0.464
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
50.9±25.0 µM
Hemolytic Cytotoxic
50% Hemolysis | 50.9±25.0 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria. | Biochim Biophys Acta | 2013
Evidence 2 Activity

Activity

(28 ± 3.2)% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
(28 ± 3.2)% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of BP16 as a non-toxic cell-penetrating peptide with highly efficient drug delivery properties. | Org Biomol Chem | 2014
Evidence 3 Activity

Activity

IC50
Toxicity
40.0±7.1 µM
Cytotoxic
IC50 | 40.0±7.1 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Identification of BP16 as a non-toxic cell-penetrating peptide with highly efficient drug delivery properties. | Org Biomol Chem | 2014
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis