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Peptide record

TPDB06377

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB06377
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb PD_Hemolysis
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RRLFRRILRWL
Physicochemical Analysis
C74H125N27O12
ANDCEQGHKMPSTYV
R
1584.98
13.00
5
0
6
+5
-0.92
-0.427
141.82
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
347.01
0
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
3
L
0
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
11
C74H125N27O12
1584.98
13.00
+5
-0.92
-0.427
Evidence Records 10 records
Evidence 1 Activity

Activity

18.94% Cell death
Toxicity
150 µg/mL
Cytotoxic
18.94% Cell death | 150 | µg/mL | target cell: Bovine mammary epithelial cells MAC-T

Target

Bovine mammary epithelial cells MAC-T

Source & Reference

NA
DBAASP
RW-BP100-4D, a Promising Antimicrobial Candidate With Broad-Spectrum Bactericidal Activity | Front Microbiol | 2022
Evidence 2 Activity

Activity

1.19±0.05% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
1.19±0.05% Hemolysis | 100 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
RW-BP100-4D, a Promising Antimicrobial Candidate With Broad-Spectrum Bactericidal Activity | Front Microbiol | 2022
Evidence 3 Activity

Activity

17.23±3.08% Cell death
Toxicity
150 µg/mL
Hemolytic Cytotoxic
17.23±3.08% Cell death | 150 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
RW-BP100-4D, a Promising Antimicrobial Candidate With Broad-Spectrum Bactericidal Activity | Front Microbiol | 2022
Evidence 4 Activity

Activity

48.67±2.17% Hemolysis
Toxicity
300 µg/mL
Hemolytic Cytotoxic
48.67±2.17% Hemolysis | 300 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
RW-BP100-4D, a Promising Antimicrobial Candidate With Broad-Spectrum Bactericidal Activity | Front Microbiol | 2022
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
4.9±1.0 µM
Hemolytic Cytotoxic
50% Hemolysis | 4.9±1.0 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria. | Biochim Biophys Acta | 2013
Evidence 6 Activity

Activity

42.2% Cell death
Toxicity
150 µg/mL
Cytotoxic
42.2% Cell death | 150 | µg/mL | target cell: Bovine mammary epithelial cells MAC-T

Target

Bovine mammary epithelial cells MAC-T

Source & Reference

NA
DBAASP
RW-BP100-4D, a Promising Antimicrobial Candidate With Broad-Spectrum Bactericidal Activity | Front Microbiol | 2022
Evidence 7 Activity

Activity

4.70±0.49% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
4.70±0.49% Hemolysis | 100 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
RW-BP100-4D, a Promising Antimicrobial Candidate With Broad-Spectrum Bactericidal Activity | Front Microbiol | 2022
Evidence 8 Activity

Activity

41.82±2.27% Hemolysis
Toxicity
150 µg/mL
Hemolytic Cytotoxic
41.82±2.27% Hemolysis | 150 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
RW-BP100-4D, a Promising Antimicrobial Candidate With Broad-Spectrum Bactericidal Activity | Front Microbiol | 2022
Evidence 9 Activity

Activity

56.67±6.33% Hemolysis
Toxicity
300 µg/mL
Hemolytic Cytotoxic
56.67±6.33% Hemolysis | 300 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
RW-BP100-4D, a Promising Antimicrobial Candidate With Broad-Spectrum Bactericidal Activity | Front Microbiol | 2022
Evidence 10 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis