TPDB

3D PDB MODEL

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TPDB ID TPDB06375

Activity

Antibacterial Anticancer Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept CAFPdb HemoPI Hemolytic2 PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 11-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

KWLRRVWRWWR

FASTA

>TPDB06375|Antibacterial;Anticancer;Antifungal;Hemolysis;Toxicity|length=11
KWLRRVWRWWR

Formula C85H122N28O12

Absent Amino Acids ANDCEQGHIMFPSTY

Common Amino Acids RW

Mass 1728.08

PI 12.88

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +5

Boman Index -3.66

Hydrophobicity -1.591

Aliphatic Index 61.82

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 22000

Absorbance 280nm 1273.09

Polar Residues 0

number

0

A

4

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

1

K

0

M

0

F

0

P

0

S

0

T

4

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 1

Length

11

Formula

C85H122N28O12

Mass

1728.08

PI

12.88

Net Charge

+5

Boman Index

-3.66

Hydrophobicity

-1.591

Evidence 1 Activity

Activity

Activity Endpoint 100% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

100% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Discovery of potent antimicrobial peptide analogs of Ixosin-B. | Bioorg Med Chem Lett | 2012

Evidence 2 Activity

Activity

Activity Endpoint 70.7% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

70.7% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Design, Synthesis, and Antimicrobial Activities of Novel Functional Peptides Against Gram-positive and Gram-negative Bacteria. | Chem Biol Drug Des | 2019

Evidence 3 Activity

Activity

Activity Endpoint 71% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

71% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

NOVEL PEPTIDE AND USES THEREOF | Patent US 20160130301 A1 | 2016

Evidence 4 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 %

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.22578463]100% hemolysis at 100µM against human red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Bioorg Med Chem Lett. 2012 Jun 15 22(12):4185-8.

Evidence 5 Hemolysis

Source & Reference

source HemoPI PD_Hemolysis

Database Source PD_Hemolysis