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Peptide record

TPDB06374

Antibacterial Anticancer Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB06374
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KRLRRVWRRWR
Physicochemical Analysis
C75H126N32O12
ANDCEQGHIMFPSTY
R
1668.03
13.10
7
0
4
+7
1.66
-2.245
61.82
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
11000
659.46
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
1
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
11
C75H126N32O12
1668.03
13.10
+7
1.66
-2.245
Evidence Records 2 records
Evidence 1 Activity

Activity

3% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
3% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of potent antimicrobial peptide analogs of Ixosin-B. | Bioorg Med Chem Lett | 2012
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
3 %
Hemolytic
Hemolytic_activity: [Ref.22578463]3% hemolysis at 100µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Bioorg Med Chem Lett. 2012 Jun 15 22(12):4185-8.