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Peptide record

TPDB06365

11 poly-arginine Arg11 poly-arginine (Arg11) R11 Antibacterial Anticancer Blood-Brain Barrier Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB06365
11 poly-arginine Arg11 poly-arginine (Arg11) R11
Antibacterial Anticancer Blood-Brain Barrier Cell-penetrating Peptides
Anti-infective peptides Cancer-related peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia dbACP B3Pred BBPpredict CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Anticancer, Blood-Brain Barrier, and other sources) peptide sequence curated from AntiBP3, Peptipedia, dbACP, and other sources, with an available 3D structural model.
Sequence
RRRRRRRRRRR
Physicochemical Analysis
C66H134N44O12
ANDCEQGHILKMFPSTWYV
R
1736.08
13.40
11
0
0
+11
8.91
-4.500
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
11
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 11 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C66H134N44O12
1736.08
13.40
+11
8.91
-4.500
Free
L
Linear
Cationic
Linear
Free
Similarity
ArgArgArgArgArgArgArgArgArgArgArg
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 8 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Assay & Model

mice
Origin/Source
highly regulated CPP-dependent manner

Source & Reference

NA
B3Pdb
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

A549

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Nucleic acid (pDNA)
Cytosol
In vitro
CCCGGGGCCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

Rat Primary Cortical Cultures

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
Heparan sulfate receptor-mediated endocytic pathway
In vitro
CCCGGGGCCCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Mice (Kunming species, 22 g, sex-matched)
Mice (Kunming species, 22 g, sex-matched)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
Gamma-aminobutyric acid (GABA)
In vivo
CCCGGGGCCCC
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Target

Hek293 Cells, Rat Cardiomyocytes

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
Cargo(1–9): IEKELAQQY , Cargo(8–18): QYQNADAITLE, Cargo(1–11): IEKELAQQYQN
Cytosol
Slow Ca2+ uptake in vesicles incubated with Arg11 in comparison with untreated controls.
In vitro
CCCCCCCCC
Evidence 6 Activity

Activity

Cell-penetrating Peptides

Target

Hek 293T Cells,Hek-Blue Il-1R Cells, THP-1 Cells, Primary Human Monocytes

Assay & Model

C57BL/6J mice
C57BL/6J mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
SLAMF1-derived peptide P7
Both P7-Arg11 and P7-Pen [but not Pen and Arg11 or P7 without CPP], significantly reduced LPS-mediated IFNβ and TNF mRNA expression)
In vitro and in vivo
CCCCCCCCCCCSCSSSSSCCCCCTTCSSSCCCCCCTTTTHHHHC
Evidence 7 Activity

Activity

Cell-penetrating Peptides

Target

Ucb Cells (I.E., T24)

Assay & Model

Mice bearing T24 orthotopic tumors (Female nude (Balb/c nu/nu, 4–6 weeks age))
Mice bearing T24 orthotopic tumors (Female nude (Balb/c nu/nu, 4–6 weeks age))

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L Cationic
Synthetic
FITC-tagged p53 C-terminus (p53C).
Cytosol
A dose-dependent increase in fluorescence intensity was observed in R11-p53C and R11-Con peptides in contrast, p53C peptides had lower fluorescent intensity
In vitro and in vivo
Evidence 8 Activity

Activity

Cell-penetrating Peptides

Target

Escherichia coli

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
PNA and APIM peptide
Cytosol
Energy dependent pathway
In vitro
CCCGGGGCCCC
Additional Detail Fields 1 fields
CCCGGGGCCCC CCCCCCCCC CCCCCCCCCCCSCSSSSSCCCCCTTCSSSCCCCCCTTTTHHHHC