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Peptide record

TPDB06354

Antibacterial Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB06354
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 11-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
WWSYVRRWRSR
Physicochemical Analysis
C77H108N26O15
ANDCEQGHILKMFPT
R
1637.87
12.40
4
0
5
+4
-2.92
-1.764
26.36
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
17990
1098.38
3
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
2
S
0
T
3
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 2 T: 0 W: 3 Y: 1 V: 1
Chemical Descriptors
11
C77H108N26O15
1637.87
12.40
+4
-2.92
-1.764
Evidence Records 2 records
Evidence 1 Activity

Activity

3% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
3% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship of potent antimicrobial peptide analogs of Ixosin-B amide. | Bioorg Med Chem Lett | 2013
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
1.3 %
Hemolytic
Hemolytic_activity: [Ref.23570790]3.4±1.3% hemolysis at 100µM against human red blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
Bioorg Med Chem Lett. 2013 May 15 23(10):2929-32.