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Peptide record

TPDB06344

Antibacterial Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB06344
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 11-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LRLKKYKVPQL
Physicochemical Analysis
C66H116N18O14
ANDCEGHIMFSTW
LK
1385.76
10.91
4
0
5
+4
2.26
-0.636
132.73
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
107.52
2
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
3
L
3
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 3 K: 3 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
11
C66H116N18O14
1385.76
10.91
+4
2.26
-0.636
Evidence Records 4 records
Evidence 1 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Broad-Spectrum Antimicrobial Activity and Low Cytotoxicity against Human Cells of a Peptide Derived from Bovine ?S1-Casein | Molecules | 2018
Evidence 2 Activity

Activity

5% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
5% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Broad-Spectrum Antimicrobial Activity and Low Cytotoxicity against Human Cells of a Peptide Derived from Bovine ?S1-Casein | Molecules | 2018
Evidence 3 Activity

Activity

23.54% Hemolysis
Toxicity
512 µM
Hemolytic Cytotoxic
23.54% Hemolysis | 512 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Broad-Spectrum Antimicrobial Activity and Low Cytotoxicity against Human Cells of a Peptide Derived from Bovine ?S1-Casein | Molecules | 2018
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.2978375]Hemolysis 0% at 16µM Hemolysis 23.54% at 512µM against human red blood cells | Cytotoxicity: [Ref.29783753] In 293 cells, The peptide had no cytotoxic activity at concentrations of 1-512 µM. The cell survival rates are 100%, 96%, 98%, 105%, 104%, 112%, 116%, 114% and 103% at concentrations of 1, 2, 4, 8, 16, 32, 64, 128, 256, 512 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Molecules. 2018 May 19 23(5). pii: E1220.