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Peptide record

TPDB06268

Antibacterial Anticancer Antifungal Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB06268
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
SLLSLIRLLIT
Physicochemical Analysis
C58H108N14O15
ANDCEQGHKMFPWYV
L
1241.58
11.05
1
0
7
+1
-2.21
1.927
248.18
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
5
L
0
K
0
M
0
F
0
P
2
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 5 K: 0 M: 0 F: 0 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C58H108N14O15
1241.58
11.05
+1
-2.21
1.927
Evidence Records 3 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
50.0 µM
Hemolytic Cytotoxic
0% Hemolysis | 50.0 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of leucine-substituted decoralin analogs with lower hemolytic activity. | J Pept Sci | 2017
Evidence 2 Activity

Activity

50% Cell death
Toxicity
25 µM
Cytotoxic
50% Cell death | 25 | µM | target cell: Normal breast cells MCF-10a

Target

Normal breast cells MCF-10a

Source & Reference

NA
DBAASP
Natural and redesigned wasp venom peptides with selective antitumoral activity. | Beilstein J Org Chem | 2018
Evidence 3 Activity

Activity

MHC
Toxicity
50.00 µm
Hemolytic Cytotoxic
Hemolytic_activity: Human red blood cells: MHC=50.00 µmol/L | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Beilstein J Org Chem. 2018 Jul 6 14:1693-1703.