Back to search

Peptide record

TPDB06243

Antibacterial Anticancer Antifungal Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB06243
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
KLWKKWKKWLK
Physicochemical Analysis
C81H126N20O12
ARNDCEQGHIMFPSTYV
K
1572.02
11.21
6
0
5
+6
-0.73
-1.682
70.91
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
16500
1049.61
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
6
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
11
C81H126N20O12
1572.02
11.21
+6
-0.73
-1.682
Evidence Records 4 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
<400 µM
Hemolytic Cytotoxic
5% Hemolysis | <400 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cell specificity, anti-inflammatory activity, and plausible bactericidal mechanism of designed Trp-rich model antimicrobial peptides | Biochim Biophys Acta | 2009
Evidence 2 Activity

Activity

IC50
Toxicity
51±35 µM
Cytotoxic
IC50 | 51±35 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators. | Int J Antimicrob Agents | 2019
Evidence 3 Activity

Activity

0% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent antimicrobial peptides with selectivity for Bacillus anthracis over human erythrocytes. | Int J Antimicrob Agents | 2011
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Antimicrob Agents. 2019 Jun 53(6):868-872.