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Peptide record

TPDB06227

Antibacterial Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB06227
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 11-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
FAKWAFKWAKK
Physicochemical Analysis
C73H103N17O12
RNDCEQGHILMPSTYV
K
1410.73
11.00
4
0
7
+4
-2.51
-0.582
27.27
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
11000
779.74
0
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
4
K
0
M
2
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 2 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
11
C73H103N17O12
1410.73
11.00
+4
-2.51
-0.582
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

B. subtilis ATCC 6633

Source & Reference

NA

Other

active against Gram+ B. subtilis ATCC 6633 (MIC 25 ug/ml), M. luteus ATCC 10240 (MIC 25 ug/ml), S. aureus ATCC 6538p (MIC 100 ug/ml), S. epidermidi
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

M. luteus ATCC 10240

Source & Reference

NA

Other

active against Gram+ B. subtilis ATCC 6633 (MIC 25 ug/ml), M. luteus ATCC 10240 (MIC 25 ug/ml), S. aureus ATCC 6538p (MIC 100 ug/ml), S. epidermidis ATCC 12228 (MIC 100 ug/ml), Gram- E
Evidence 3 Activity

Activity

MIC
Antibacterial
100 µg/mL

Target

Staphylococcus aureus ATCC 6538p

Source & Reference

NA

Other

against Gram+ B. subtilis ATCC 6633 (MIC 25 ug/ml), M. luteus ATCC 10240 (MIC 25 ug/ml), S. aureus ATCC 6538p (MIC 100 ug/ml), S. epidermidis ATCC 12228 (MIC 100 ug/ml), Gram- E. coli ATCC 25922 (MIC 100 ug/ml), S.
Evidence 4 Activity

Activity

MIC
Antibacterial
100 µg/mL

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

NA

Other

MIC 25 ug/ml), M. luteus ATCC 10240 (MIC 25 ug/ml), S. aureus ATCC 6538p (MIC 100 ug/ml), S. epidermidis ATCC 12228 (MIC 100 ug/ml), Gram- E. coli ATCC 25922 (MIC 100 ug/ml), S. dysentariae ATCC 9752 (MIC 50 ug/ml), S.typ
Evidence 5 Activity

Activity

MIC
Antibacterial
100 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

), S. aureus ATCC 6538p (MIC 100 ug/ml), S. epidermidis ATCC 12228 (MIC 100 ug/ml), Gram- E. coli ATCC 25922 (MIC 100 ug/ml), S. dysentariae ATCC 9752 (MIC 50 ug/ml), S.typhimorium ATCC 14028 (MIC 200 ug/ml), K.pne
Evidence 6 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

S. dysentariae ATCC 9752

Source & Reference

NA

Other

ml), S. epidermidis ATCC 12228 (MIC 100 ug/ml), Gram- E. coli ATCC 25922 (MIC 100 ug/ml), S. dysentariae ATCC 9752 (MIC 50 ug/ml), S.typhimorium ATCC 14028 (MIC 200 ug/ml), K.pneumonia ATCC 10031 (MIC 200 ug/ml), and P.
Evidence 7 Activity

Activity

MIC
Antibacterial
200 µg/mL

Target

S.typhimorium ATCC 14028

Source & Reference

NA

Other

g/ml), Gram- E. coli ATCC 25922 (MIC 100 ug/ml), S. dysentariae ATCC 9752 (MIC 50 ug/ml), S.typhimorium ATCC 14028 (MIC 200 ug/ml), K.pneumonia ATCC 10031 (MIC 200 ug/ml), and P.aeruginosa ATCC 27853) (MIC 200 ug/ml).
Evidence 8 Activity

Activity

MIC
Antibacterial
200 µg/mL

Target

K.pneumonia ATCC 10031

Source & Reference

NA

Other

g/ml), S. dysentariae ATCC 9752 (MIC 50 ug/ml), S.typhimorium ATCC 14028 (MIC 200 ug/ml), K.pneumonia ATCC 10031 (MIC 200 ug/ml), and P.aeruginosa ATCC 27853) (MIC 200 ug/ml).
Evidence 9 Activity

Activity

5% Hemolysis
Toxicity
>=200 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | >=200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Activity optimization of an undecapeptide analogue derived from a frog-skin antimicrobial peptide | Mol Cells | 2011