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Peptide record

TPDB06222

Antibacterial Hemolysis Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB06222
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, HemoPI, and other sources, with an available 3D structural model.
Sequence
KRFKKFFKKLK
Physicochemical Analysis
C75H124N20O12
ANDCEQGHIMPSTWYV
K
1497.94
11.90
7
0
4
+7
2.80
-1.427
35.45
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
6
K
0
M
3
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 6 M: 0 F: 3 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C75H124N20O12
1497.94
11.90
+7
2.80
-1.427
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
Toxicity
98.51 µg/mL
Cytotoxic
IC50 | 98.51 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Lipidation of Naturally Occurring α-Helical Antimicrobial Peptides as a Promising Strategy for Drug Design | Int J Mol Sci | 2023
Evidence 2 Activity

Activity

IC50
Toxicity
142.0 µg/mL
Cytotoxic
IC50 | 142.0 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Lipidation of Naturally Occurring α-Helical Antimicrobial Peptides as a Promising Strategy for Drug Design | Int J Mol Sci | 2023
Evidence 3 Activity

Activity

1% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 512 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Evidence 4 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Impact of lipidation site on the activity of α-helical antimicrobial peptides | Bioorg Chem | 2024
Evidence 5 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis