Back to search

Peptide record

TPDB06221

Antibacterial Antifungal Hemolysis Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB06221
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KKLLKWLLKLL
Physicochemical Analysis
C71H126N16O12
ARNDCEQGHIMFPSTYV
L
1395.88
11.00
4
0
7
+4
-1.25
0.573
212.73
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
394.02
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
6
L
4
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 6 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
11
C71H126N16O12
1395.88
11.00
+4
-1.25
0.573
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.6 µg/mL

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram+ B. subtilis ATCC 6633 (MIC 1.6 ug/ml), S. aureus ATCC 6538p (MIC 1.6 ug/ml), S.epidermis ATCC 12228 (MIC 1.6 ug/ml), M. luteus
Evidence 2 Activity

Activity

MIC
Antibacterial
1.6 µg/mL

Target

Staphylococcus aureus ATCC 6538p

Source & Reference

dbAMP DRAMP

Other

active against Gram+ B. subtilis ATCC 6633 (MIC 1.6 ug/ml), S. aureus ATCC 6538p (MIC 1.6 ug/ml), S.epidermis ATCC 12228 (MIC 1.6 ug/ml), M. luteus ATCC 10240 (MIC 1.6 ug/ml), Gram- E. c
Evidence 3 Activity

Activity

MIC
Antibacterial
1.6 µg/mL

Target

S.epidermis ATCC 12228

Source & Reference

dbAMP DRAMP

Other

gainst Gram+ B. subtilis ATCC 6633 (MIC 1.6 ug/ml), S. aureus ATCC 6538p (MIC 1.6 ug/ml), S.epidermis ATCC 12228 (MIC 1.6 ug/ml), M. luteus ATCC 10240 (MIC 1.6 ug/ml), Gram- E. coli ATCC 25922 (MIC 6.3 ug/ml), S. dysen
Evidence 4 Activity

Activity

MIC
Antibacterial
1.6 µg/mL

Target

M. luteus ATCC 10240

Source & Reference

dbAMP DRAMP

Other

1.6 ug/ml), S. aureus ATCC 6538p (MIC 1.6 ug/ml), S.epidermis ATCC 12228 (MIC 1.6 ug/ml), M. luteus ATCC 10240 (MIC 1.6 ug/ml), Gram- E. coli ATCC 25922 (MIC 6.3 ug/ml), S. dysentariae ATCC 9752 (MIC 3.1 ug/ml), S. t
Evidence 5 Activity

Activity

MIC
Antibacterial
6.3 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

/ml), S.epidermis ATCC 12228 (MIC 1.6 ug/ml), M. luteus ATCC 10240 (MIC 1.6 ug/ml), Gram- E. coli ATCC 25922 (MIC 6.3 ug/ml), S. dysentariae ATCC 9752 (MIC 3.1 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. p
Evidence 6 Activity

Activity

MIC
Antibacterial
3.1 µg/mL

Target

S. dysentariae ATCC 9752

Source & Reference

dbAMP DRAMP

Other

6 ug/ml), M. luteus ATCC 10240 (MIC 1.6 ug/ml), Gram- E. coli ATCC 25922 (MIC 6.3 ug/ml), S. dysentariae ATCC 9752 (MIC 3.1 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 3.1 ug/ml), and
Evidence 7 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

S. typhimorium ATCC 14028

Source & Reference

dbAMP DRAMP

Other

/ml), Gram- E. coli ATCC 25922 (MIC 6.3 ug/ml), S. dysentariae ATCC 9752 (MIC 3.1 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 3.1 ug/ml), and P. aeruginosa ATCC 27853 (MIC 25 ug/ml).
Evidence 8 Activity

Activity

MIC
Antibacterial
3.1 µg/mL

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

dbAMP DRAMP

Other

/ml), S. dysentariae ATCC 9752 (MIC 3.1 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 3.1 ug/ml), and P. aeruginosa ATCC 27853 (MIC 25 ug/ml).
Evidence 9 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

, S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 3.1 ug/ml), and P. aeruginosa ATCC 27853 (MIC 25 ug/ml).
Evidence 10 Activity

Activity

MIC
Antifungal
1.6 µg/mL

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against Gram+ B. subtilis ATCC 6633 (MIC 1.6 ug/ml), S. aureus ATCC 6538p (MIC 1.6 ug/ml), S.epidermis ATCC 12228 (MIC 1.6 ug/ml), M. luteus
Evidence 11 Activity

Activity

MIC
Antifungal
1.6 µg/mL

Target

Staphylococcus aureus ATCC 6538p

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against Gram+ B. subtilis ATCC 6633 (MIC 1.6 ug/ml), S. aureus ATCC 6538p (MIC 1.6 ug/ml), S.epidermis ATCC 12228 (MIC 1.6 ug/ml), M. luteus ATCC 10240 (MIC 1.6 ug/ml), Gram- E. c
Evidence 12 Activity

Activity

MIC
Antifungal
1.6 µg/mL

Target

S.epidermis ATCC 12228

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

gainst Gram+ B. subtilis ATCC 6633 (MIC 1.6 ug/ml), S. aureus ATCC 6538p (MIC 1.6 ug/ml), S.epidermis ATCC 12228 (MIC 1.6 ug/ml), M. luteus ATCC 10240 (MIC 1.6 ug/ml), Gram- E. coli ATCC 25922 (MIC 6.3 ug/ml), S. dysen
Evidence 13 Activity

Activity

MIC
Antifungal
1.6 µg/mL

Target

M. luteus ATCC 10240

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

1.6 ug/ml), S. aureus ATCC 6538p (MIC 1.6 ug/ml), S.epidermis ATCC 12228 (MIC 1.6 ug/ml), M. luteus ATCC 10240 (MIC 1.6 ug/ml), Gram- E. coli ATCC 25922 (MIC 6.3 ug/ml), S. dysentariae ATCC 9752 (MIC 3.1 ug/ml), S. t
Evidence 14 Activity

Activity

MIC
Antifungal
6.3 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

/ml), S.epidermis ATCC 12228 (MIC 1.6 ug/ml), M. luteus ATCC 10240 (MIC 1.6 ug/ml), Gram- E. coli ATCC 25922 (MIC 6.3 ug/ml), S. dysentariae ATCC 9752 (MIC 3.1 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. p
Evidence 15 Activity

Activity

MIC
Antifungal
3.1 µg/mL

Target

S. dysentariae ATCC 9752

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

6 ug/ml), M. luteus ATCC 10240 (MIC 1.6 ug/ml), Gram- E. coli ATCC 25922 (MIC 6.3 ug/ml), S. dysentariae ATCC 9752 (MIC 3.1 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 3.1 ug/ml), and
Evidence 16 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

S. typhimorium ATCC 14028

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

/ml), Gram- E. coli ATCC 25922 (MIC 6.3 ug/ml), S. dysentariae ATCC 9752 (MIC 3.1 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 3.1 ug/ml), and P. aeruginosa ATCC 27853 (MIC 25 ug/ml).
Evidence 17 Activity

Activity

MIC
Antifungal
3.1 µg/mL

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

/ml), S. dysentariae ATCC 9752 (MIC 3.1 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 3.1 ug/ml), and P. aeruginosa ATCC 27853 (MIC 25 ug/ml).
Evidence 18 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 3.1 ug/ml), and P. aeruginosa ATCC 27853 (MIC 25 ug/ml).
Evidence 19 Activity

Activity

58% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
58% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
De novo generation of antimicrobial LK peptides with a single tryptophan at the critical amphipathic interface. | J Pept Sci | 2009
Evidence 20 Activity

Activity

7% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
7% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
De novo generation of antimicrobial LK peptides with a single tryptophan at the critical amphipathic interface. | J Pept Sci | 2009
Evidence 21 Activity

Activity

5% Hemolysis
Toxicity
6.3 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 6.3 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
De novo generation of antimicrobial LK peptides with a single tryptophan at the critical amphipathic interface. | J Pept Sci | 2009
Evidence 22 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis