Back to search

Peptide record

TPDB06218

Antibacterial Antiparasitic Toxicity standard

11 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB06218

Activity

Antibacterial Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia i2APP

Sequence_Type

standard

Has_Modification No

Description A 11-aa standard natural multi-activity (Antibacterial, Antiparasitic, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and i2APP, with an available 3D structural model.

Sequence

RRWQWRMKKLG

FASTA

>TPDB06218|Antibacterial;Antiparasitic;Toxicity|length=11
RRWQWRMKKLG

Formula C70H113N25O13S1

Absent Amino Acids ANDCEHIFPSTYV

Common Amino Acids R

Mass 1544.89

PI 12.71

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +5

Boman Index 0.51

Hydrophobicity -1.936

Aliphatic Index 35.45

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 11000

Absorbance 280nm 712.03

Polar Residues 1

number

Amino Acid Distribution

A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 1 K: 2 M: 1 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0

Length

Formula

C70H113N25O13S1

Mass

1544.89

12.71

Net Charge

Boman Index

0.51

Hydrophobicity

-1.936

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30-40 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 30-40 ug/ml) amd S. aureus (MIC 30-50 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30-50 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 30-40 ug/ml) amd S. aureus (MIC 30-50 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 30-40 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 30-40 ug/ml) amd S. aureus (MIC 30-50 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 30-50 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 30-40 ug/ml) amd S. aureus (MIC 30-50 ug/ml).

Evidence 5 Activity

Activity

Activity Endpoint 26% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 30 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

26% Hemolysis | 30 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Synergistic bactericide and antibiotic effects of dimeric, tetrameric, or palindromic peptides containing the RWQWR motif against Gram-positive and Gram-negative strains | RSC Adv | 2019

Evidence 6 Activity

Activity

Activity Endpoint 5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

5% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Comparative antimicrobial activity and mechanism of action of bovine lactoferricin-derived synthetic peptides. | Biometals | 2011

Evidence 7 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

- | NA | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs. | PLoS One | 2010