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Peptide record

TPDB06202

Antibacterial Anticancer Hemolysis Toxicity standard

11 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB06202

Activity

Antibacterial Anticancer Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF HemoPI Hemolytic2 PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 11-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.

Sequence

FLGWLFKWASK

FASTA

>TPDB06202|Antibacterial;Anticancer;Hemolysis;Toxicity|length=11
FLGWLFKWASK

Formula C72H99N15O13

Absent Amino Acids RNDCEQHIMPTYV

Common Amino Acids LKFW

Mass 1382.67

PI 10.60

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +2

Boman Index -5.13

Hydrophobicity 0.382

Aliphatic Index 80.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 11000

Absorbance 280nm 795.56

Polar Residues 1

number

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 2 M: 0 F: 2 P: 0 S: 1 T: 0 W: 2 Y: 0 V: 0

Length

Formula

C72H99N15O13

Mass

1382.67

10.60

Net Charge

Boman Index

-5.13

Hydrophobicity

0.382

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism B. subtilis ATCC 6633

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram+ B. subtilis ATCC 6633 (MIC 25 ug/ml), M. luteus ATCC 10240 (MIC 12.5 ug/ml), S. aureus ATCC 6538p (MIC 25 ug/ml), S. epidermid

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µg/mL

Target

Target Organism M. luteus ATCC 10240

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram+ B. subtilis ATCC 6633 (MIC 25 ug/ml), M. luteus ATCC 10240 (MIC 12.5 ug/ml), S. aureus ATCC 6538p (MIC 25 ug/ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), Gram- E.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 6538p

Source & Reference

Database Source NA

Other

Evidence Text

gainst Gram+ B. subtilis ATCC 6633 (MIC 25 ug/ml), M. luteus ATCC 10240 (MIC 12.5 ug/ml), S. aureus ATCC 6538p (MIC 25 ug/ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), Gram- E. coli ATCC 25922 (MIC 50 ug/ml), S. dy

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism Staphylococcus epidermidis ATCC 12228

Source & Reference

Database Source NA

Other

Evidence Text

IC 25 ug/ml), M. luteus ATCC 10240 (MIC 12.5 ug/ml), S. aureus ATCC 6538p (MIC 25 ug/ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), Gram- E. coli ATCC 25922 (MIC 50 ug/ml), S. dysentariae ATCC 9752 (MIC 25 ug/ml), S.typh

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

ml), S. aureus ATCC 6538p (MIC 25 ug/ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), Gram- E. coli ATCC 25922 (MIC 50 ug/ml), S. dysentariae ATCC 9752 (MIC 25 ug/ml), S.typhimorium ATCC 14028 (MIC 200 ug/ml), K. pn

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism S. dysentariae ATCC 9752

Source & Reference

Database Source NA

Other

Evidence Text

g/ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), Gram- E. coli ATCC 25922 (MIC 50 ug/ml), S. dysentariae ATCC 9752 (MIC 25 ug/ml), S.typhimorium ATCC 14028 (MIC 200 ug/ml), K. pneumonia ATCC 10031 (MIC 50 ug/ml), and P.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 200 µg/mL

Target

Target Organism S.typhimorium ATCC 14028

Source & Reference

Database Source NA

Other

Evidence Text

ug/ml), Gram- E. coli ATCC 25922 (MIC 50 ug/ml), S. dysentariae ATCC 9752 (MIC 25 ug/ml), S.typhimorium ATCC 14028 (MIC 200 ug/ml), K. pneumonia ATCC 10031 (MIC 50 ug/ml), and P.aeruginosa ATCC 27853) (MIC 200 ug/ml).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism K. pneumonia ATCC 10031

Source & Reference

Database Source NA

Other

Evidence Text

g/ml), S. dysentariae ATCC 9752 (MIC 25 ug/ml), S.typhimorium ATCC 14028 (MIC 200 ug/ml), K. pneumonia ATCC 10031 (MIC 50 ug/ml), and P.aeruginosa ATCC 27853) (MIC 200 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint 100% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

100% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Systematic peptide engineering and structural characterization to search for the shortest antimicrobial peptide analogue of gaegurin 5 | J Biol Chem | 2004

Evidence 10 Activity

Activity

Activity Endpoint 5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 25 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

5% Hemolysis | 25 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Activity optimization of an undecapeptide analogue derived from a frog-skin antimicrobial peptide | Mol Cells | 2011

Evidence 11 Hemolysis

Source & Reference

source HemoPI PD_Hemolysis

Database Source PD_Hemolysis