TPDB

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 21.3 µM

Target

Target Organism S. mutants

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against Gram+ bacteria S. mutants (MIC 21.3 uM), S. aureus (MIC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 42.5 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against Gram+ bacteria S. mutants (MIC 21.3 uM), S. aureus (MIC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aerugino

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 21.3 µM

Target

Target Organism E. faecium

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against Gram+ bacteria S. mutants (MIC 21.3 uM), S. aureus (MIC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulni

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10.6 µM

Target

Target Organism Escherichia coli O-157

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

s (MIC 21.3 uM), S. aureus (MIC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 21.3 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

IC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 42.5 µM

Target

Target Organism V. vulnificus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21.3 uM), M. furfur (MIC 42.5 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 42.5 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21.3 uM), M. furfur (MIC 42.5 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 21.3 µM

Target

Target Organism T. beigelii

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

inosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21.3 uM), M. furfur (MIC 42.5 uM).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 42.5 µM

Target

Target Organism M. furfur

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21.3 uM), M. furfur (MIC 42.5 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 21.3 µM

Target

Target Organism S. mutants

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against Gram+ bacteria S. mutants (MIC 21.3 uM), S. aureus (MIC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 42.5 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Evidence Text

Active against Gram+ bacteria S. mutants (MIC 21.3 uM), S. aureus (MIC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aerugino

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 21.3 µM

Target

Target Organism E. faecium

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Evidence Text

Active against Gram+ bacteria S. mutants (MIC 21.3 uM), S. aureus (MIC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulni

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10.6 µM

Target

Target Organism Escherichia coli O-157

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Evidence Text

s (MIC 21.3 uM), S. aureus (MIC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 21.3 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Evidence Text

IC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 42.5 µM

Target

Target Organism V. vulnificus

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Evidence Text

21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21.3 uM), M. furfur (MIC 42.5 uM).

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 42.5 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Evidence Text

157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21.3 uM), M. furfur (MIC 42.5 uM).

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 21.3 µM

Target

Target Organism T. beigelii

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Evidence Text

inosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21.3 uM), M. furfur (MIC 42.5 uM).

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 42.5 µM

Target

Target Organism M. furfur

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Evidence Text

vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21.3 uM), M. furfur (MIC 42.5 uM).

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 21.3 µM

Target

Target Organism S. mutants

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against Gram+ bacteria S. mutants (MIC 21.3 uM), S. aureus (MIC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 42.5 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against Gram+ bacteria S. mutants (MIC 21.3 uM), S. aureus (MIC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aerugino

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 21.3 µM

Target

Target Organism E. faecium

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against Gram+ bacteria S. mutants (MIC 21.3 uM), S. aureus (MIC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulni

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 10.6 µM

Target

Target Organism Escherichia coli O-157

Source & Reference

Database Source DRAMP

Other

Evidence Text

s (MIC 21.3 uM), S. aureus (MIC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 21.3 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source DRAMP

Other

Evidence Text

IC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 42.5 µM

Target

Target Organism V. vulnificus

Source & Reference

Database Source DRAMP

Other

Evidence Text

21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21.3 uM), M. furfur (MIC 42.5 uM).

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 42.5 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21.3 uM), M. furfur (MIC 42.5 uM).

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 21.3 µM

Target

Target Organism T. beigelii

Source & Reference

Database Source DRAMP

Other

Evidence Text

inosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21.3 uM), M. furfur (MIC 42.5 uM).

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 42.5 µM

Target

Target Organism M. furfur

Source & Reference

Database Source DRAMP

Other

Evidence Text

vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21.3 uM), M. furfur (MIC 42.5 uM).

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 21.3 µM

Target

Target Organism S. mutants

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against Gram+ bacteria S. mutants (MIC 21.3 uM), S. aureus (MIC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 42.5 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against Gram+ bacteria S. mutants (MIC 21.3 uM), S. aureus (MIC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aerugino

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 21.3 µM

Target

Target Organism E. faecium

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against Gram+ bacteria S. mutants (MIC 21.3 uM), S. aureus (MIC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulni

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 10.6 µM

Target

Target Organism Escherichia coli O-157

Source & Reference

Database Source DRAMP

Other

Evidence Text

s (MIC 21.3 uM), S. aureus (MIC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 21.3 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source DRAMP

Other

Evidence Text

IC 42.5 uM), and E. faecium (MIC 21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 42.5 µM

Target

Target Organism V. vulnificus

Source & Reference

Database Source DRAMP

Other

Evidence Text

21.3 uM) and gram- bacteria E. coli O-157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21.3 uM), M. furfur (MIC 42.5 uM).

Evidence 34 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 42.5 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

157 (MIC 10.6 uM), P. aeruginosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21.3 uM), M. furfur (MIC 42.5 uM).

Evidence 35 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 21.3 µM

Target

Target Organism T. beigelii

Source & Reference

Database Source DRAMP

Other

Evidence Text

inosa (MIC 21.3 uM), and V. vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21.3 uM), M. furfur (MIC 42.5 uM).

Evidence 36 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 42.5 µM

Target

Target Organism M. furfur

Source & Reference

Database Source DRAMP

Other

Evidence Text

vulnificus (MIC 42.5 uM) and fungi C. albicans (MIC 42.5 uM), T. beigelii (MIC 21.3 uM), M. furfur (MIC 42.5 uM).

Evidence 37 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Urechis unicinctus

Family Tachykinin

Evidence 38 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 3.12-100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 3.12-100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial effect and membrane-active mechanism of Urechistachykinins, neuropeptides derived from Urechis unicinctus. | FEBS Lett | 2008

Evidence 39 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.18570895] Has no hemolytic activities against human erythrocyte cells.

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

FEBS Lett. 2008 Jul 9 582(16):2463-2466.