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Peptide record

TPDB06154

[RW]5 Antibacterial Antifungal Antiviral Cell-penetrating Peptides Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB06154
[RW]5
Antibacterial Antifungal Antiviral Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CAFPdb DRAMP dbAMP AI4AVP CPPsite3.0
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Antifungal, Antiviral, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
RWRWRWRWRW
Physicochemical Analysis
C85H112N30O11
ANDCEQGHILKMFPSTYV
RW
1730.02
13.00
5
0
5
+5
-5.20
-2.700
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
27500
1589.58
0
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
5
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 5 Y: 0 V: 0
Chemical Descriptors
10
C85H112N30O11
1730.02
13.00
+5
-5.20
-2.700
Free
L
Cationic
Cyclic
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Cationic
Synthetic
Silver nanoparticles (AgNPs)
Mitochondria
Enhance uptake of AgNP
Phagocytosis or passive nonspecific diffusion
In vitro
CCSCCCCCC
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
76 µM
Hemolytic Cytotoxic
50% Hemolysis | 76 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Length effects in antimicrobial peptides of the (RW)n series | Antimicrob Agents Chemother | 2007
Additional Detail Fields 1 fields
CCSCCCCCC