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Peptide record

TPDB06147

Antibacterial Antifungal Toxicity standard

10 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB06147

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FLPGLLAGLL

FASTA

>TPDB06147|Antibacterial;Antifungal;Toxicity|length=10
FLPGLLAGLL

Formula C51H84N10O11

Absent Amino Acids RNDCEQHIKMSTWYV

Common Amino Acids L

Mass 1013.29

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 7

Net Charge -0

Boman Index -3.63

Hydrophobicity 2.120

Aliphatic Index 205.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 5 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C51H84N10O11

Mass

1013.29

6.02

Net Charge

-0

Boman Index

-3.63

Hydrophobicity

2.120

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.3 µM

Target

Target Organism Escherichia coli HP101BA 7601c

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli HP101BA 7601c (MIC 12.3 uM), K. pneumonia PTCC1388 (MIC 9.8 uM), M. luteus PTCC1625 (MIC 8.3 uM), and S. aureus PTCC1

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.8 µM

Target

Target Organism K. pneumonia PTCC1388

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli HP101BA 7601c (MIC 12.3 uM), K. pneumonia PTCC1388 (MIC 9.8 uM), M. luteus PTCC1625 (MIC 8.3 uM), and S. aureus PTCC1431 (MIC 10.6 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.3 µM

Target

Target Organism M. luteus PTCC1625

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli HP101BA 7601c (MIC 12.3 uM), K. pneumonia PTCC1388 (MIC 9.8 uM), M. luteus PTCC1625 (MIC 8.3 uM), and S. aureus PTCC1431 (MIC 10.6 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10.6 µM

Target

Target Organism Staphylococcus aureus PTCC1431

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

c (MIC 12.3 uM), K. pneumonia PTCC1388 (MIC 9.8 uM), M. luteus PTCC1625 (MIC 8.3 uM), and S. aureus PTCC1431 (MIC 10.6 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.3 µM

Target

Target Organism Escherichia coli HP101BA 7601c

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli HP101BA 7601c (MIC 12.3 uM), K. pneumonia PTCC1388 (MIC 9.8 uM), M. luteus PTCC1625 (MIC 8.3 uM), and S. aureus PTCC1

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.8 µM

Target

Target Organism K. pneumonia PTCC1388

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Evidence Text

Active against E. coli HP101BA 7601c (MIC 12.3 uM), K. pneumonia PTCC1388 (MIC 9.8 uM), M. luteus PTCC1625 (MIC 8.3 uM), and S. aureus PTCC1431 (MIC 10.6 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8.3 µM

Target

Target Organism M. luteus PTCC1625

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Evidence Text

Active against E. coli HP101BA 7601c (MIC 12.3 uM), K. pneumonia PTCC1388 (MIC 9.8 uM), M. luteus PTCC1625 (MIC 8.3 uM), and S. aureus PTCC1431 (MIC 10.6 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10.6 µM

Target

Target Organism Staphylococcus aureus PTCC1431

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Evidence Text

c (MIC 12.3 uM), K. pneumonia PTCC1388 (MIC 9.8 uM), M. luteus PTCC1625 (MIC 8.3 uM), and S. aureus PTCC1431 (MIC 10.6 uM).

Evidence 9 Activity

Activity

Activity Endpoint 2% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 60 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

2% Hemolysis | 60 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Identification and characterization of novel antibacterial peptides from skin secretions of Euphlyctis cyanophlyctis. | Int J Pept Res Ther | 2012

Evidence 10 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.Int J Pept Res Ther(2012)18 107.]<3% hemolytic activity at 60 µg/ml against human red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Int. J. Pept. Res. Ther. 2012 18:107-115.