Back to search

Peptide record

TPDB06143

Antibacterial Antifungal Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB06143
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb ToxinPred 3.0
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AIGHCLGATL
Physicochemical Analysis
C41H70N12O12S1
RNDEQKMFPSWYV
AGL
955.14
7.15
1
0
5
+0
-0.89
1.350
137.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
0
R
0
N
0
D
1
C
0
E
0
Q
2
G
1
H
1
I
2
L
0
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 1 I: 1 L: 2 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C41H70N12O12S1
955.14
7.15
+0
-0.89
1.350
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
33.5 µM

Target

L. innocua CICC 10417

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ bacteria B. subtilis CICC 10034, S. aureus CICC 10306, L. innocua CICC 10417 (MIC 33.5 uM) B. megaterium CICC 10448 (8 uM) Gram- bacteria E. coli CICC 10293, P:. aeruginosa CICC
Evidence 2 Activity

Activity

MIC
Antibacterial
4.2-8.3 µM

Target

S. Paratyphi CICC 10437

Source & Reference

dbAMP DRAMP

Other

sa CICC 21636, A. faecalis ATCC 8750, S. marcescens ATCC 4112, E. cloacae CICC 21539, and S. Paratyphi CICC 10437 (MIC 4.2-8.3 uM). This species is used as a traditional Chinese medicine.
Evidence 3 Activity

Activity

MIC
Antifungal
33.5 µM

Target

L. innocua CICC 10417

Source & Reference

dbAMP DRAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ bacteria B. subtilis CICC 10034, S. aureus CICC 10306, L. innocua CICC 10417 (MIC 33.5 uM) B. megaterium CICC 10448 (8 uM) Gram- bacteria E. coli CICC 10293, P:. aeruginosa CICC
Evidence 4 Activity

Activity

MIC
Antifungal
4.2-8.3 µM

Target

S. Paratyphi CICC 10437

Source & Reference

dbAMP DRAMP CAFPdb

Other

sa CICC 21636, A. faecalis ATCC 8750, S. marcescens ATCC 4112, E. cloacae CICC 21539, and S. Paratyphi CICC 10437 (MIC 4.2-8.3 uM). This species is used as a traditional Chinese medicine.
Evidence 5 Activity

Activity

0% Killing
Toxicity
50 µg/mL
Cytotoxic
0% Killing | 50 | µg/mL | target cell: Human hepatocyte cells HL-7702 (L02)

Target

Human hepatocyte cells HL-7702 (L02)

Source & Reference

NA
DBAASP
Antimicrobial peptide from mucus of Andrias davidianus: screening and purification by magnetic cell membrane separation technique. | Int J Antimicrob Agents | 2017
Evidence 6 Activity

Activity

13% Killing
Toxicity
100 µg/mL
Cytotoxic
13% Killing | 100 | µg/mL | target cell: Human hepatocyte cells HL-7702 (L02)

Target

Human hepatocyte cells HL-7702 (L02)

Source & Reference

NA
DBAASP
Antimicrobial peptide from mucus of Andrias davidianus: screening and purification by magnetic cell membrane separation technique. | Int J Antimicrob Agents | 2017
Evidence 7 Activity

Activity

48% Killing
Toxicity
200 µg/mL
Cytotoxic
48% Killing | 200 | µg/mL | target cell: Human hepatocyte cells HL-7702 (L02)

Target

Human hepatocyte cells HL-7702 (L02)

Source & Reference

NA
DBAASP
Antimicrobial peptide from mucus of Andrias davidianus: screening and purification by magnetic cell membrane separation technique. | Int J Antimicrob Agents | 2017
Evidence 8 Activity

Activity

0% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptide from mucus of Andrias davidianus: screening and purification by magnetic cell membrane separation technique. | Int J Antimicrob Agents | 2017
Evidence 9 Activity

Activity

4.3±0.16% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
4.3±0.16% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptide from mucus of Andrias davidianus: screening and purification by magnetic cell membrane separation technique. | Int J Antimicrob Agents | 2017
Evidence 10 Activity

Activity

16.3±2.16% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
16.3±2.16% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptide from mucus of Andrias davidianus: screening and purification by magnetic cell membrane separation technique. | Int J Antimicrob Agents | 2017
Evidence 11 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.28461043] The cell viability of HL-7702 cells is 100.0±0.30%, 100.5±0.52%, 86.8±2.10% and 52.1±1.81% at peptide concentrations of 25, 50, 100 and 200 µg/ml. ##The cell viability of HREpiC cells is 100.1±0.20%, 103.1±1.20%, 82.3±1.84% and 50.3±2.05%

Source & Reference

NA
DRAMP
Int J Antimicrob Agents.?2017 Jul 50(1):41-46. doi: 10.1016/j.ijantimicag.2017.02.013.