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Peptide record

TPDB06131

Antibacterial Antiviral Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB06131
Antibacterial Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AI4AVP
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Antiviral, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and AI4AVP, with an available 3D structural model.
Sequence
WKKIRVRLSA
Physicochemical Analysis
C58H101N19O12
NDCEQGHMFPTY
RK
1256.56
12.42
4
0
5
+4
0.91
-0.420
117.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
437.70
1
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
2
K
0
M
0
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
10
C58H101N19O12
1256.56
12.42
+4
0.91
-0.420
Evidence Records 8 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
2 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 2 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Enhanced amphiphilic profile of a short ?-stranded peptide improves its antimicrobial activity. | PLoS One | 2015
Evidence 2 Activity

Activity

2% Hemolysis
Toxicity
4-32 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 4-32 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Enhanced amphiphilic profile of a short ?-stranded peptide improves its antimicrobial activity. | PLoS One | 2015
Evidence 3 Activity

Activity

4.1±1.2% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
4.1±1.2% Hemolysis | 64 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Enhanced amphiphilic profile of a short ?-stranded peptide improves its antimicrobial activity. | PLoS One | 2015
Evidence 4 Activity

Activity

5% Hemolysis
Toxicity
3.125 µM
Hemolytic Cytotoxic
5% Hemolysis | 3.125 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational modification of a dendrimeric peptide with antimicrobial activity: consequences on membrane-binding and biological properties. | Amino Acids | 2016
Evidence 5 Activity

Activity

14% Hemolysis
Toxicity
6.25 µM
Hemolytic Cytotoxic
14% Hemolysis | 6.25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational modification of a dendrimeric peptide with antimicrobial activity: consequences on membrane-binding and biological properties. | Amino Acids | 2016
Evidence 6 Activity

Activity

20% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
20% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational modification of a dendrimeric peptide with antimicrobial activity: consequences on membrane-binding and biological properties. | Amino Acids | 2016
Evidence 7 Activity

Activity

36% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
36% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational modification of a dendrimeric peptide with antimicrobial activity: consequences on membrane-binding and biological properties. | Amino Acids | 2016
Evidence 8 Activity

Activity

62% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
62% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational modification of a dendrimeric peptide with antimicrobial activity: consequences on membrane-binding and biological properties. | Amino Acids | 2016