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Peptide record

TPDB06129

cR10 mCherry-R10 R10-anti-gyrA PNA/scPNA P7 R10 Antibacterial Antiviral Cell-penetrating Peptides standard

10 amino acids

3D PDB MODEL

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TPDB ID TPDB06129

Peptide_Name

cR10 mCherry-R10 R10-anti-gyrA PNA/scPNA P7 R10

Activity

Antibacterial Antiviral Cell-penetrating Peptides

Activity_category_statistics

Anti-infective peptides Delivery and barrier-penetrating peptides

Database_Source

AntiBP3 Peptipedia AI4AVP dbAMP 3.0 DRAVP 2.0 CellPPD-MOD CPPsite3.0

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural multi-activity (Antibacterial, Antiviral, and Cell-penetrating Peptides) peptide sequence curated from AntiBP3, Peptipedia, AI4AVP, and other sources, with an available 3D structural model.

Sequence

RRRRRRRRRR

FASTA

>TPDB06129|Antibacterial;Antiviral;Cell-penetrating Peptides|length=10
RRRRRRRRRR

Formula C60H122N40O11

Absent Amino Acids ANDCEQGHILKMFPSTWYV

Common Amino Acids R

Mass 1579.89

PI 13.35

Basic Residues 10

Acidic Residues 0

Hydrophobic Residues 0

Net Charge +10

Boman Index 8.10

Hydrophobicity -4.500

Aliphatic Index 0.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C60H122N40O11

Mass

1579.89

13.35

Net Charge

+10

Boman Index

8.10

Hydrophobicity

-4.500

C_terminal_Modification

Free

Chirality

Ionic_State

Cationic

Linearity

Linear Cyclic

N_terminal_Modification

Free

SMILES

N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)O

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Rat Primary Cortical Cultures

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Uptake Mechanism Heparan sulfate receptor-mediated endocytic pathway

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCSCCCC

Evidence 2 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Vero Cells And Hk-2 Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type Copper/zinc superoxide dismutase (SOD1)

Uptake Efficiency TAT-SOD1 and R10-SOD1 could efficiently enter cells.

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCSCCCC

Evidence 3 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line S. Pyogenes Strains

Assay & Model

In Vitro Model G. mellonella Larvae

In Vivo Model G. mellonella Larvae

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type anti-gyrA antisense PNAs and scrambled PNAs [scPNAs]

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCCCC

Evidence 4 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line U2Os Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Cyclic L

Source of Peptide Synthetic

Cargo Type TAMRA-labelled ubiquitin (Ub) via disulfide linkage

Subcellular Localization Cytosol

Uptake Efficiency Ub-cR10, showed almost no distribution within the cytosol

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCSCCCC

Evidence 5 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line A549 And Nci-H1299 Cells

Assay & Model

In Vitro Model Female BALB/c-nu/nu nude mice

In Vivo Model Female BALB/c-nu/nu nude mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Cargo Type Homeobox A9 (HOXA9) protein

Subcellular Localization Cytoplasm and nucleus

Uptake Efficiency

R10-HOXA9 protein was localized in both the cytoplasm and the nucleus of the cells and the intracellular concentration increased in a dose-dependent manner.

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCCCCC

Evidence 6 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Assay & Model

In Vitro Model Normal BL6 mice, dystrophin-null mdx4cv mice and ∆R4 transgenic mice

In Vivo Model Normal BL6 mice, dystrophin-null mdx4cv mice and ∆R4 transgenic mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Non-natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Palmitoylated (Pal) R16/17-GFP protein

In Vitro or In Vivo In vivo

Evidence 7 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line HeLa Ccl-2 Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Cyclic L Cationic

Source of Peptide Synthetic

Cargo Type mCherry

Subcellular Localization Cytoplasm and nucleus

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCTTCSSCCSCC

Evidence 8 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line A549 Cell

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type FAM, rhodamine123, Doxorubicin

Subcellular Localization Nucleus

Uptake Efficiency FR10 showed the highest uptake

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCTTCC

DSSP_Secondary_Structure

CCCCCSCCCC CCCCCC CCCCCCC CCCCCCCCTTCSSCCSCC CCCCTTCC