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Peptide record

TPDB06125

Antibacterial Antifungal Hemolysis Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB06125
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb PD_Hemolysis
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLLKFIKKLL
Physicochemical Analysis
C59H105N13O11
ARNDCEQHMPSTWYV
L
1172.56
10.84
3
0
6
+3
-0.70
1.040
195.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
4
L
3
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 4 K: 3 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C59H105N13O11
1172.56
10.84
+3
-0.70
1.040
Evidence Records 13 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
3 5 9 8 7 %
[Ref.27862650]3% hemolysis at 100 µg/ml , 5% hemolysis at 200 µg/ml , 9% hemolysis at 300 µg/ml , 8% hemolysis at 400 µg/ml , 7% hemolysis at 500 µg/ml against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
J Pept Sci. 2016 Nov 22(11-12):731-736. doi: 10.1002/psc.2939.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

3% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
3% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin. | J Pept Sci | 2016
Evidence 3 Activity

Activity

5% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin. | J Pept Sci | 2016
Evidence 4 Activity

Activity

8% Hemolysis
Toxicity
300-500 µg/mL
Hemolytic Cytotoxic
8% Hemolysis | 300-500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin. | J Pept Sci | 2016
Evidence 5 Activity

Activity

10% Hemolysis
Toxicity
100-500 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 100-500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin. | J Pept Sci | 2016
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
13.57 µM
Hemolytic Cytotoxic
50% Hemolysis | 13.57 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthetic analogs of anoplin show improved antimicrobial activities. | J Pept Sci | 2013
Evidence 7 Activity

Activity

5% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin. | J Pept Sci | 2016
Evidence 8 Activity

Activity

18% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
18% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin. | J Pept Sci | 2016
Evidence 9 Activity

Activity

20% Hemolysis
Toxicity
300 µg/mL
Hemolytic Cytotoxic
20% Hemolysis | 300 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin. | J Pept Sci | 2016
Evidence 10 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic
Hemolytic_activity: [Ref.27862650]0% hemolysis at 55µg/ml , 7% hemolysis at 100µg/ml , 17% hemolysis at 200µg/ml , 24% hemolysis at 300 µg/ml , 33% hemolysis at 400µg/ml , 35% hemolysis at 500 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2016 Nov 22(11-12):731-736. doi: 10.1002/psc.2939.
Evidence 11 Activity

Activity

% Hemolysis
Toxicity
3 %
Hemolytic
Hemolytic_activity: [Ref.27862650]3% hemolysis at 100 µg/ml , 5% hemolysis at 200 µg/ml , 9% hemolysis at 300 µg/ml , 8% hemolysis at 400 µg/ml , 7% hemolysis at 500 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2016 Nov 22(11-12):731-736. doi: 10.1002/psc.2939.
Evidence 12 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic
Hemolytic_activity: [Ref.27862650]10% hemolysis at 50 µg/ml , 12% hemolysis at 100 µg/ml , 10% hemolysis at 400 µg/ml , 11% hemolysis at 500 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2016 Nov 22(11-12):731-736. doi: 10.1002/psc.2939.
Evidence 13 Hemolysis

Activity

3 5 9 8 7 %
% Hemolysis
[Ref.27862650]3% hemolysis at 100 µg/ml , 5% hemolysis at 200 µg/ml , 9% hemolysis at 300 µg/ml , 8% hemolysis at 400 µg/ml , 7% hemolysis at 500 µg/ml against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

PD_Hemolysis
J Pept Sci. 2016 Nov 22(11-12):731-736. doi: 10.1002/psc.2939.
DRAMP4
PD_Hemolysis