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Peptide record

TPDB06120

CycloP1 CyLoP-1 CyLoP1 LP-P3 Antibacterial Anticancer Antifungal Cell-penetrating Peptides Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB06120
CycloP1 CyLoP-1 CyLoP1 LP-P3
Antibacterial Anticancer Antifungal Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CAFPdb dbAMP CellPPD CellPPD-MOD CPPsite3.0 ToxinPred 3.0
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
CRWRWKCCKK
Physicochemical Analysis
C61H97N21O11S3
ANDEQGHILMFPSTYV
CK
1396.76
10.32
5
0
2
+5
0.17
-1.500
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
11125
796.49
3
Residue Composition
number
0
A
2
R
0
N
0
D
3
C
0
E
0
Q
0
G
0
H
0
I
0
L
3
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 3 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
10
C61H97N21O11S3
1396.76
10.32
+5
0.17
-1.500
Free
L
Cationic
Linear Cyclic
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)O N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)O N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 6 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

6-8 week old female BALB/c mice
6-8 week old female BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein and DNA (Nucleic acid) encoding T-cell epitopes
In vivo
CCCCCCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Neuro2A

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
Peptide-based polyplexes (PAA)
Improved transfection efficiency
In vitro
CHHHHHHHTSCCCCCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

C-26, MCF-7, A2780

Assay & Model

Four to five week old female BALB/c mice
Four to five week old female BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Cyclic L
Protein derived
PEGylated PAMAM containing SN38
Significantly higher than SN38 loaded PEG- G4 PAMAM and G4 PAMAM
In vitro and in vivo
CCSCCCCCCCTTHHHHTTTC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293 T Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
rNef-Vpr-Gp160-P24 protein
Able to deliver rNef-VprGp160-P24 peptide
In vitro
CCCCCCGGGC
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Six to eight-week-old female BALB/c mice
Six to eight-week-old female BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Cyclic L Cationic
Protein derived
In vivo
CCCSTHHHHHHHHHHHTTCCSSSCTHHHHHHHHCC
Evidence 6 Activity

Activity

Cell-penetrating Peptides

Target

P. aeruginosa and MRSA

Assay & Model

BALb/c mice (8 weeks, 18–20 g, male)
BALb/c mice (8 weeks, 18–20 g, male)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
Liposomes (LP)
Membrane damage
In vitro and in vivo
CCCCGGGCSSSCGGGCCCGGGGSCCC
Additional Detail Fields 1 fields
CCCCCCCCCC CHHHHHHHTSCCCCCCC CCSCCCCCCCTTHHHHTTTC CCCCCCGGGC CCCSTHHHHHHHHHHHTTCCSSSCTHHHHHHHHCC CCCCGGGCSSSCGGGCCCGGGGSCCC