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Peptide record

TPDB06096

Antibacterial Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB06096
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 10-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SGKLWWRRKK
Physicochemical Analysis
C63H101N21O12
ANDCEQHIMFPTYV
K
1344.63
12.43
5
0
3
+5
0.47
-1.990
39.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
11000
818.07
1
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
3
K
0
M
0
F
0
P
1
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 3 M: 0 F: 0 P: 0 S: 1 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
10
C63H101N21O12
1344.63
12.43
+5
0.47
-1.990
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E. coli (MIC 6 uM), S. aureus (MIC 12 uM), P. aeruginosa (MIC 12 uM)
Evidence 2 Activity

Activity

MIC
Antibacterial
12 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 6 uM), S. aureus (MIC 12 uM), P. aeruginosa (MIC 12 uM)
Evidence 3 Activity

Activity

MIC
Antibacterial
12 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 6 uM), S. aureus (MIC 12 uM), P. aeruginosa (MIC 12 uM)
Evidence 4 Activity

Activity

2% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
2% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of Short Membrane Selective Antimicrobial Peptides Containing Tryptophan and Arginine Residues for Improved Activity, Salt-Resistance, and Biocompatibility | Biotechnol Bioeng | 2014
Evidence 5 Activity

Activity

3% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
3% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of Short Membrane Selective Antimicrobial Peptides Containing Tryptophan and Arginine Residues for Improved Activity, Salt-Resistance, and Biocompatibility | Biotechnol Bioeng | 2014
Evidence 6 Activity

Activity

% Hemolysis
Toxicity
2.5 %
Hemolytic
Hemolytic_activity: [Ref.23860860] 2.5% hemolysis at 100 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Microbiol. 2012 2012:764834. ##Biotechnol Bioeng. 2014 Jan 111(1):37-49. doi: 10.1002/bit.25003.