Back to search

Peptide record

TPDB06091

Antibacterial Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB06091
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia
standard
No
A 10-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, DRAMP, and Peptipedia, with an available 3D structural model.
Sequence
ALLKRIKTLL
Physicochemical Analysis
C55H105N15O12
NDCEQGHMFPSWYV
L
1168.53
11.64
3
0
6
+3
0.21
0.850
205.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
4
L
2
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 4 K: 2 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C55H105N15O12
1168.53
11.64
+3
0.21
0.850
Evidence Records 2 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship study of anoplin. | J Pept Sci | 2005
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.32654770]After 1 h of incubation, Ano-1β, similar to their parent peptide anoplin, maintained more than 80 % cell viability of the two cells at all tested concentrations. After incubating for 24 h, Ano-1β still maintained more than 80 % cell viability of HEK 293 T cells at all tested concentrations but displayed cytotoxicity against Hela cells at the highest concentration (256 µM). The cell viability of Hela after 24 h of incubation is around 80%.

Source & Reference

NA
DRAMP
Int J Med Microbiol. 2020 Jul 310(5):151433. doi: 10.1016/j.ijmm.2020.151433. Epub 2020 May 27.