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Peptide record

TPDB06047

Antibacterial Hemolysis Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB06047
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia PD_Hemolysis
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GLLKRIKALL
Physicochemical Analysis
C53H101N15O11
NDCEQHMFPSTWYV
L
1124.48
11.64
3
0
6
+3
0.08
0.880
205.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
4
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 4 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C53H101N15O11
1124.48
11.64
+3
0.08
0.880
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus ATCC 25923 (MIC 8 ug/ml) and E. coli ATCC 25922 (MIC 16 ug/ml). slightly more active than the WT.
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

Active against S. aureus ATCC 25923 (MIC 8 ug/ml) and E. coli ATCC 25922 (MIC 16 ug/ml). slightly more active than the WT.
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
97 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 97 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship study of anoplin. | J Pept Sci | 2005
Evidence 4 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.32654770]After 1 h of incubation, Ano-8β, similar to their parent peptide anoplin, maintained more than 80 % cell viability of the two cells at all tested concentrations. After incubating for 24 h, Ano-8β still maintained more than 80 % cell viability of HEK 293 T cells at all tested concentrations but displayed cytotoxicity against Hela cells at the highest concentration (256 µM). The cell viability of Hela after 24 h of incubation is around 70%

Source & Reference

NA
DRAMP
Int J Med Microbiol. 2020 Jul 310(5):151433. doi: 10.1016/j.ijmm.2020.151433. Epub 2020 May 27.
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis