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Peptide record

TPDB06040

Antibacterial Hemolysis Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB06040
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
GLLKIIKTLL
Physicochemical Analysis
C54H102N12O12
ARNDCEQHMFPSWYV
L
1111.48
10.60
2
0
6
+2
-0.73
1.530
234.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
4
L
2
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 4 K: 2 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C54H102N12O12
1111.48
10.60
+2
-0.73
1.530
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

NA

Other

Active against S. aureus ATCC 25923 (MIC 2 ug/ml) and E. coli ATCC 25922 (MIC 2 ug/ml). slightly more active than the WT.
Evidence 2 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

Active against S. aureus ATCC 25923 (MIC 2 ug/ml) and E. coli ATCC 25922 (MIC 2 ug/ml). slightly more active than the WT.
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
29 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 29 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship study of anoplin. | J Pept Sci | 2005
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis