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Peptide record

TPDB06015

Antibacterial Antifungal Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB06015
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KLLKWWKKLL
Physicochemical Analysis
C70H114N16O11
ARNDCEQGHIMFPSTYV
LK
1355.78
11.00
4
0
6
+4
-1.98
-0.220
156.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
11000
811.34
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
4
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
10
C70H114N16O11
1355.78
11.00
+4
-1.98
-0.220
Evidence Records 5 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
0% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of novel analogues of short antimicrobial peptide anoplin with improved antimicrobial activity. | J Pept Sci | 2014
Evidence 2 Activity

Activity

1% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
1% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of novel analogues of short antimicrobial peptide anoplin with improved antimicrobial activity. | J Pept Sci | 2014
Evidence 3 Activity

Activity

4% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
4% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of novel analogues of short antimicrobial peptide anoplin with improved antimicrobial activity. | J Pept Sci | 2014
Evidence 4 Activity

Activity

13% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
13% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of novel analogues of short antimicrobial peptide anoplin with improved antimicrobial activity. | J Pept Sci | 2014
Evidence 5 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic
Hemolytic_activity: [Ref.25316570] 0% hemolysis at 12.5 µg/ml , 0.5% hemolysis at 25 µg/ml , 0.5% hemolysis at 50 µg/ml , 4% hemolysis at 100 µg/ml , 14% hemolysis at 200 µg/ml against mice red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2014 Dec 20(12):945-51. doi: 10.1002/psc.2705.